{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Elmasri H"],"funding":["NICHD NIH HHS","Harvard School of Public Health","National Institutes of Health"],"pagination":["3865-73"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2775007"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(11)"],"pubmed_abstract":["Fatty acid binding protein 4 (FABP4) plays an important role in maintaining glucose and lipid homeostasis. FABP4 has been primarily regarded as an adipocyte- and macrophage-specific protein, but recent studies suggest that it may be more widely expressed. We found strong FABP4 expression in the endothelial cells (ECs) of capillaries and small veins in several mouse and human tissues, including the heart and kidney. FABP4 was also detected in the ECs of mature human placental vessels and infantile hemangiomas, the most common tumor of infancy and ECs. In most of these cases, FABP4 was detected in both the nucleus and cytoplasm. FABP4 mRNA and protein levels were significantly induced in cultured ECs by VEGF-A and bFGF treatment. The effect of VEGF-A on FABP4 expression was inhibited by chem"],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pubmed_title":["Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells."],"pmcid":["PMC2775007"],"funding_grant_id":["5T32 HD007466-12","T32 HD007466"],"pubmed_authors":["Cataltepe S","Ghelfi E","Kozakewich H","Teper Y","Ince TA","Karaaslan C","Weng M","Bischoff J","Elmasri H"],"additional_accession":[]},"is_claimable":false,"name":"Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells.","description":"Fatty acid binding protein 4 (FABP4) plays an important role in maintaining glucose and lipid homeostasis. FABP4 has been primarily regarded as an adipocyte- and macrophage-specific protein, but recent studies suggest that it may be more widely expressed. We found strong FABP4 expression in the endothelial cells (ECs) of capillaries and small veins in several mouse and human tissues, including the heart and kidney. FABP4 was also detected in the ECs of mature human placental vessels and infantile hemangiomas, the most common tumor of infancy and ECs. In most of these cases, FABP4 was detected in both the nucleus and cytoplasm. FABP4 mRNA and protein levels were significantly induced in cultured ECs by VEGF-A and bFGF treatment. The effect of VEGF-A on FABP4 expression was inhibited by chem","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Nov","modification":"2026-03-16T16:55:27.715Z","creation":"2019-03-27T00:26:27Z"},"accession":"S-EPMC2775007","cross_references":{"pubmed":["19625659"],"doi":["10.1096/fj.09-134882"]}}