biostudies-literatureGriffin CANIAMS NIH HHSNIGMS NIH HHS649-61https://www.ebi.ac.uk/biostudies/studies/S-EPMC2780437biostudies-literatureUnknown17(5)Odorant receptors (ORs) in the olfactory epithelium bind to volatile small molecules leading to the perception of smell. ORs are expressed in many tissues but their functions are largely unknown. We show multiple ORs display distinct mRNA expression patterns during myogenesis in vitro and muscle regeneration in vivo. Mouse OR23 (MOR23) expression is induced during muscle regeneration when muscle cells are extensively fusing and plays a key role in regulating migration and adhesion of muscle cells in vitro, two processes common during tissue repair. A soluble ligand for MOR23 is secreted by muscle cells in vitro and muscle tissue in vivo. MOR23 is necessary for proper skeletal muscle regeneration as loss of MOR23 leads to increased myofiber branching, commonly associated with muscular dystrophy. Together these data identify a functional role for an OR outside of the nose and suggest a larger role for ORs during tissue repair.Developmental cellMOR23 promotes muscle regeneration and regulates cell adhesion and migration.PMC2780437T32-GM08367R01 AR052730-02R01 AR052730-03R01 AR052730-04T32 GM008367AR-047314AR-052730R01 AR051372R01 AR052730-01A1AR-051372R01 AR047314R01 AR052730Pavlath GKKafadar KAGriffin CAfalseMOR23 promotes muscle regeneration and regulates cell adhesion and migration.Odorant receptors (ORs) in the olfactory epithelium bind to volatile small molecules leading to the perception of smell. ORs are expressed in many tissues but their functions are largely unknown. We show multiple ORs display distinct mRNA expression patterns during myogenesis in vitro and muscle regeneration in vivo. Mouse OR23 (MOR23) expression is induced during muscle regeneration when muscle cells are extensively fusing and plays a key role in regulating migration and adhesion of muscle cells in vitro, two processes common during tissue repair. A soluble ligand for MOR23 is secreted by muscle cells in vitro and muscle tissue in vivo. MOR23 is necessary for proper skeletal muscle regeneration as loss of MOR23 leads to increased myofiber branching, commonly associated with muscular dystrophy. Together these data identify a functional role for an OR outside of the nose and suggest a larger role for ORs during tissue repair.2009-01-01T00:00:00Z2009 Nov2024-10-17T23:45:00.932Z2019-03-27T00:26:42ZS-EPMC27804371992287010.1016/j.devcel.2009.09.004