{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lisik W"],"funding":["NIAID NIH HHS"],"pagination":["e8020"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2780702"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(12)"],"pubmed_abstract":["<h4>Background</h4>The allochimeric MHC class I molecule [alpha1h1/u]-RT1.Aa that contains donor-type (Wistar Furth, WF; RT1u) epitopes displayed on recipient-type (ACI, RT1a) administered in conjunction with sub-therapeutic dose of cyclosporine (CsA) induces indefinite survival of heterotopic cardiac allografts in rat model. In vascularized transplantation models, the spleen contributes to graft rejection by generating alloantigen reactive T cells. The immune response in allograft rejection involves a cascade of molecular events leading to the formation of immunological synapses between T cells and the antigen-presenting cells.<h4>Methodology/principal findings</h4>To elucidate the molecular pathways involved in the immunosuppressive function of allochimeric molecule we performed microarr"],"journal":["PloS one"],"pubmed_title":["Down regulation of genes involved in T cell polarity and motility during the induction of heart allograft tolerance by allochimeric MHC I."],"pmcid":["PMC2780702"],"funding_grant_id":["R01 AI049945","R01 AI49945"],"pubmed_authors":["Tejpal N","Lisik W","Kloc M","Skelton TS","Ganachari M","Ghobrial RM","Gong Y","Bremer EG"],"additional_accession":[]},"is_claimable":false,"name":"Down regulation of genes involved in T cell polarity and motility during the induction of heart allograft tolerance by allochimeric MHC I.","description":"<h4>Background</h4>The allochimeric MHC class I molecule [alpha1h1/u]-RT1.Aa that contains donor-type (Wistar Furth, WF; RT1u) epitopes displayed on recipient-type (ACI, RT1a) administered in conjunction with sub-therapeutic dose of cyclosporine (CsA) induces indefinite survival of heterotopic cardiac allografts in rat model. In vascularized transplantation models, the spleen contributes to graft rejection by generating alloantigen reactive T cells. The immune response in allograft rejection involves a cascade of molecular events leading to the formation of immunological synapses between T cells and the antigen-presenting cells.<h4>Methodology/principal findings</h4>To elucidate the molecular pathways involved in the immunosuppressive function of allochimeric molecule we performed microarr","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Dec","modification":"2026-04-07T14:44:53.217Z","creation":"2019-03-26T23:06:28Z"},"accession":"S-EPMC2780702","cross_references":{"pubmed":["19956540"],"doi":["10.1371/journal.pone.0008020"]}}