{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dharajiya N"],"funding":["NIAID NIH HHS","NIEHS NIH HHS","NHLBI NIH HHS"],"pagination":["e8172"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2791840"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(12)"],"pubmed_abstract":["According to the current paradigm, allergic airway inflammation is mediated by Th2 cytokines and pro-inflammatory chemokines. Since allergic inflammation is self-limited, we hypothesized that allergen challenge simultaneously induces anti-inflammatory genes to counter-balance the effects of Th2 cytokines and chemokines. To identify these putative anti-inflammatory genes, we compared the gene expression profile in the lungs of ragweed-sensitized mice four hours after challenge with either PBS or ragweed extract (RWE) using a micro-array platform. Consistent with our hypothesis, RWE challenge concurrently upregulated Th1-associated early target genes of the Il12/Stat4 pathway, such as p47 and p65 GTPases (Iigp, Tgtp and Gbp1), Socs1, Cxcl9, Cxcl10 and Gadd45g with the Th2 genes Il4, Il5, Ccl"],"journal":["PloS one"],"pubmed_title":["Allergen challenge induces Ifng dependent GTPases in the lungs as part of a Th1 transcriptome response in a murine model of allergic asthma."],"pmcid":["PMC2791840"],"funding_grant_id":["N01HV28184","P30 ES006676","1P01 AI062885","N01-HV28184","1R01 HL071163","R01 HL071163","P01 AI062885"],"pubmed_authors":["Dharajiya N","Vaidya S","Sur S","Boldogh I","Sinha M","Luxon B"],"additional_accession":[]},"is_claimable":false,"name":"Allergen challenge induces Ifng dependent GTPases in the lungs as part of a Th1 transcriptome response in a murine model of allergic asthma.","description":"According to the current paradigm, allergic airway inflammation is mediated by Th2 cytokines and pro-inflammatory chemokines. Since allergic inflammation is self-limited, we hypothesized that allergen challenge simultaneously induces anti-inflammatory genes to counter-balance the effects of Th2 cytokines and chemokines. To identify these putative anti-inflammatory genes, we compared the gene expression profile in the lungs of ragweed-sensitized mice four hours after challenge with either PBS or ragweed extract (RWE) using a micro-array platform. Consistent with our hypothesis, RWE challenge concurrently upregulated Th1-associated early target genes of the Il12/Stat4 pathway, such as p47 and p65 GTPases (Iigp, Tgtp and Gbp1), Socs1, Cxcl9, Cxcl10 and Gadd45g with the Th2 genes Il4, Il5, Ccl","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Dec","modification":"2025-04-21T19:16:41.377Z","creation":"2019-06-06T21:47:39Z"},"accession":"S-EPMC2791840","cross_references":{"pubmed":["20027288"],"doi":["10.1371/journal.pone.0008172"]}}