biostudies-literatureHendricks AENIGMS NIH HHSS100https://www.ebi.ac.uk/biostudies/studies/S-EPMC2795871biostudies-literatureUnknown3 Suppl 7Over the past decade, genetic analysis has shifted from linkage studies, which identify broad regions containing putative trait loci, to genome-wide association studies, which detect the association of a marker with a specific phenotype. Because linkage and association analysis provide complementary information, developing a method to combine these analyses may increase the power to detect a true association. In this paper we compare a linkage score and association score test as well as a newly proposed combination of these two scores with traditional linkage and association methods.BMC proceedingsGenome-wide association and linkage analysis of quantitative traits: comparison of likelihood-ratio test and conditional score statistic.PMC2795871R01 GM031575-28R01 GM031575Dupuis JHendricks AEZhu YfalseGenome-wide association and linkage analysis of quantitative traits: comparison of likelihood-ratio test and conditional score statistic.Over the past decade, genetic analysis has shifted from linkage studies, which identify broad regions containing putative trait loci, to genome-wide association studies, which detect the association of a marker with a specific phenotype. Because linkage and association analysis provide complementary information, developing a method to combine these analyses may increase the power to detect a true association. In this paper we compare a linkage score and association score test as well as a newly proposed combination of these two scores with traditional linkage and association methods.2009-01-01T00:00:00Z2009 Dec2024-11-09T17:06:03.693Z2019-03-27T00:27:28ZS-EPMC27958712001796410.1186/1753-6561-3-s7-s100