{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["120(1)"],"submitter":["Derre L"],"pubmed_abstract":["The function of antigen-specific CD8+ T cells, which may protect against both infectious and malignant diseases, can be impaired by ligation of their inhibitory receptors, which include CTL-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1). Recently, B and T lymphocyte attenuator (BTLA) was identified as a novel inhibitory receptor with structural and functional similarities to CTLA-4 and PD-1. BTLA triggering leads to decreased antimicrobial and autoimmune T cell responses in mice, but its functions in humans are largely unknown. Here we have demonstrated that as human viral antigen-specific CD8+ T cells differentiated from naive to effector cells, their surface expression of BTLA was gradually downregulated. In marked contrast, human melanoma tumor antigen-specific effecto"],"journal":["The Journal of clinical investigation"],"pagination":["157-67"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2799219"],"repository":["biostudies-literature"],"pubmed_title":["BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination."],"pmcid":["PMC2799219"],"pubmed_authors":["Speiser DE","Rimoldi D","Pastor S","Michielin O","Olive D","Romero P","Derre L","Rivals JP","Jandus C"],"additional_accession":[]},"is_claimable":false,"name":"BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination.","description":"The function of antigen-specific CD8+ T cells, which may protect against both infectious and malignant diseases, can be impaired by ligation of their inhibitory receptors, which include CTL-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1). Recently, B and T lymphocyte attenuator (BTLA) was identified as a novel inhibitory receptor with structural and functional similarities to CTLA-4 and PD-1. BTLA triggering leads to decreased antimicrobial and autoimmune T cell responses in mice, but its functions in humans are largely unknown. Here we have demonstrated that as human viral antigen-specific CD8+ T cells differentiated from naive to effector cells, their surface expression of BTLA was gradually downregulated. In marked contrast, human melanoma tumor antigen-specific effecto","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Jan","modification":"2025-05-18T11:22:09.647Z","creation":"2025-05-18T11:22:09.647Z"},"accession":"S-EPMC2799219","cross_references":{"pubmed":["20038811"],"doi":["10.1172/JCI40070","10.1172/jci40070"]}}