biostudies-literatureUnknown120(1)Derre LThe function of antigen-specific CD8+ T cells, which may protect against both infectious and malignant diseases, can be impaired by ligation of their inhibitory receptors, which include CTL-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1). Recently, B and T lymphocyte attenuator (BTLA) was identified as a novel inhibitory receptor with structural and functional similarities to CTLA-4 and PD-1. BTLA triggering leads to decreased antimicrobial and autoimmune T cell responses in mice, but its functions in humans are largely unknown. Here we have demonstrated that as human viral antigen-specific CD8+ T cells differentiated from naive to effector cells, their surface expression of BTLA was gradually downregulated. In marked contrast, human melanoma tumor antigen-specific effectoThe Journal of clinical investigation157-67https://www.ebi.ac.uk/biostudies/studies/S-EPMC2799219biostudies-literatureBTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination.PMC2799219Speiser DERimoldi DPastor SMichielin OOlive DRomero PDerre LRivals JPJandus CfalseBTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination.The function of antigen-specific CD8+ T cells, which may protect against both infectious and malignant diseases, can be impaired by ligation of their inhibitory receptors, which include CTL-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1). Recently, B and T lymphocyte attenuator (BTLA) was identified as a novel inhibitory receptor with structural and functional similarities to CTLA-4 and PD-1. BTLA triggering leads to decreased antimicrobial and autoimmune T cell responses in mice, but its functions in humans are largely unknown. Here we have demonstrated that as human viral antigen-specific CD8+ T cells differentiated from naive to effector cells, their surface expression of BTLA was gradually downregulated. In marked contrast, human melanoma tumor antigen-specific effecto2010-01-01T00:00:00Z2010 Jan2025-05-18T11:22:09.647Z2025-05-18T11:22:09.647ZS-EPMC27992192003881110.1172/JCI4007010.1172/jci40070