{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["193(1)"],"submitter":["Zanetti MV"],"funding":["Wellcome Trust"],"pubmed_abstract":["<h4>Background</h4>White-matter hyperintensities have been associated with both schizophrenia and mood disorders, particularly bipolar disorder, but results are inconsistent across studies.<h4>Aims</h4>To examine whether white-matter hyperintensities are a vulnerability marker for psychosis or are specifically associated with bipolar disorder.<h4>Method</h4>T(2)-weighted magnetic resonance imaging data were acquired in 129 individuals with first-episode psychosis (either affective or non-affective psychoses) and 102 controls who were randomly selected from the same geographical areas. Visual white-matter hyperintensity ratings were used for group and subgroup comparisons.<h4>Results</h4>There were no statistically significant between-group differences in white-matter hyperintensity frequency or severity scores. No significant correlations were found between white-matter hyperintensity scores and duration of illness, duration of untreated psychosis, or severity of psychotic, manic or depressive symptoms.<h4>Conclusions</h4>White-matter hyperintensities are not associated with vulnerability to psychosis in general, or specifically with affective psychoses. Further, first-episode psychosis investigations using more quantitative methods are warranted to confirm these findings."],"journal":["The British journal of psychiatry : the journal of mental science"],"pagination":["25-30"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2802525"],"repository":["biostudies-literature"],"pubmed_title":["White-matter hyperintensities in first-episode psychosis."],"pmcid":["PMC2802525"],"pubmed_authors":["Busatto GF","Zanetti MV","de Castro CC","Scazufca M","Murray RM","Menezes PR","Schaufelberger MS","McGuire PK"],"additional_accession":[]},"is_claimable":false,"name":"White-matter hyperintensities in first-episode psychosis.","description":"<h4>Background</h4>White-matter hyperintensities have been associated with both schizophrenia and mood disorders, particularly bipolar disorder, but results are inconsistent across studies.<h4>Aims</h4>To examine whether white-matter hyperintensities are a vulnerability marker for psychosis or are specifically associated with bipolar disorder.<h4>Method</h4>T(2)-weighted magnetic resonance imaging data were acquired in 129 individuals with first-episode psychosis (either affective or non-affective psychoses) and 102 controls who were randomly selected from the same geographical areas. Visual white-matter hyperintensity ratings were used for group and subgroup comparisons.<h4>Results</h4>There were no statistically significant between-group differences in white-matter hyperintensity frequency or severity scores. No significant correlations were found between white-matter hyperintensity scores and duration of illness, duration of untreated psychosis, or severity of psychotic, manic or depressive symptoms.<h4>Conclusions</h4>White-matter hyperintensities are not associated with vulnerability to psychosis in general, or specifically with affective psychoses. Further, first-episode psychosis investigations using more quantitative methods are warranted to confirm these findings.","dates":{"release":"2008-01-01T00:00:00Z","publication":"2008 Jul","modification":"2025-04-18T13:19:03.181Z","creation":"2019-03-27T00:27:46Z"},"accession":"S-EPMC2802525","cross_references":{"pubmed":["18700214"],"doi":["10.1192/bjp.bp.107.038901"]}}