biostudies-literatureUnknown5(1)Coleman SK<h4>Background</h4>Specific delivery to synapses of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors with long-tailed subunits is believed to be a key event in many forms of activity-dependent changes in synaptic strength. GluA1, the best characterized long-tailed AMPA receptor subunit, contains a C-terminal class I PDZ binding motif, which mediates its interaction with scaffold and trafficking proteins, including synapse-associated protein 97 (SAP97). In GluA4, another long-tailed subunit implicated in synaptic plasticity, the PDZ motif is blocked by a single proline residue. This feature is highly conserved in vertebrates, whereas the closest invertebrate homologs of GluA4 have a canonical class I PDZ binding motif. In this work, we have examined the role of GluA4 inPloS onee8715https://www.ebi.ac.uk/biostudies/studies/S-EPMC2806832biostudies-literatureAnalysis of the potential role of GluA4 carboxyl-terminus in PDZ interactions.PMC2806832Keinanen KColeman SKCai CKalkkinen NKorpi ERfalseAnalysis of the potential role of GluA4 carboxyl-terminus in PDZ interactions.<h4>Background</h4>Specific delivery to synapses of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors with long-tailed subunits is believed to be a key event in many forms of activity-dependent changes in synaptic strength. GluA1, the best characterized long-tailed AMPA receptor subunit, contains a C-terminal class I PDZ binding motif, which mediates its interaction with scaffold and trafficking proteins, including synapse-associated protein 97 (SAP97). In GluA4, another long-tailed subunit implicated in synaptic plasticity, the PDZ motif is blocked by a single proline residue. This feature is highly conserved in vertebrates, whereas the closest invertebrate homologs of GluA4 have a canonical class I PDZ binding motif. In this work, we have examined the role of GluA4 in2010-01-01T00:00:00Z2010 Jan2026-04-16T21:11:00.837Z2019-03-26T23:07:10ZS-EPMC28068322009085210.1371/journal.pone.0008715