{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Marietta C"],"funding":["Intramural NIH HHS"],"pagination":["77-83"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2807731"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["664(1-2)"],"pubmed_abstract":["According to a recent IARC Working Group report, alcohol consumption is causally related to an increased risk of cancer of the upper aerodigestive tract, liver, colorectum, and female breast [R. Baan, K. Straif, Y. Grosse, B. Secretan, F. El Ghissassi, V. Bouvard, A. Altieri, V. Cogliano, Carcinogenicity of alcoholic beverages, Lancet Oncol. 8 (2007) 292-293]. Several lines of evidence indicate that acetaldehyde (AA), the first product of alcohol metabolism, plays a very important role in alcohol-related carcinogenesis, particularly in the esophagus. We previously proposed a model for alcohol-related carcinogenesis in which AA, generated from alcohol metabolism, reacts in cells to generate DNA lesions that form interstrand crosslinks (ICLs) [J.A. Theruvathu, P. Jaruga, R.G. Nath, M. Dizdar"],"journal":["Mutation research"],"pubmed_title":["Acetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human cells in vitro: implications for alcohol-related carcinogenesis."],"pmcid":["PMC2807731"],"funding_grant_id":["Z01 AA000083"],"pubmed_authors":["Marietta C","Brooks PJ","Thompson LH","Lamerdin JE"],"additional_accession":[]},"is_claimable":false,"name":"Acetaldehyde stimulates FANCD2 monoubiquitination, H2AX phosphorylation, and BRCA1 phosphorylation in human cells in vitro: implications for alcohol-related carcinogenesis.","description":"According to a recent IARC Working Group report, alcohol consumption is causally related to an increased risk of cancer of the upper aerodigestive tract, liver, colorectum, and female breast [R. Baan, K. Straif, Y. Grosse, B. Secretan, F. El Ghissassi, V. Bouvard, A. Altieri, V. Cogliano, Carcinogenicity of alcoholic beverages, Lancet Oncol. 8 (2007) 292-293]. Several lines of evidence indicate that acetaldehyde (AA), the first product of alcohol metabolism, plays a very important role in alcohol-related carcinogenesis, particularly in the esophagus. We previously proposed a model for alcohol-related carcinogenesis in which AA, generated from alcohol metabolism, reacts in cells to generate DNA lesions that form interstrand crosslinks (ICLs) [J.A. Theruvathu, P. Jaruga, R.G. Nath, M. Dizdar","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 May","modification":"2026-05-04T17:58:29.755Z","creation":"2019-03-27T00:28:00Z"},"accession":"S-EPMC2807731","cross_references":{"pubmed":["19428384"],"doi":["10.1016/j.mrfmmm.2009.03.011"]}}