{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rossi M"],"funding":["Intramural NIH HHS","NCI NIH HHS"],"pagination":["2429-34"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2808702"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(9)"],"pubmed_abstract":["Cancer cells evade death by over-producing specific proteins that inhibit apoptosis. One such group of proteins is the Bcl-2 family, of which Bcl-x(L) is an important member. This protein binds and inhibits BAK, another protein that promotes apoptosis. While the development of chemical inhibitors that block Bcl-x(L)-BAK association have been the focus of intense research efforts, we demonstrate in this manuscript an alternative strategy to downregulate Bcl-x(L). We have identified a small molecule (Bang52) that induces apoptosis in a lymphoblast-derived cell line by lowering levels of Bcl-x(L). Since Bang52 bears no resemblance to any chemical binder of Bcl-x(L) we believe that degradation of the protein is stimulated by a new type of pathway. These findings highlight a novel approach to the development of small molecules that promote apoptosis."],"journal":["Bioorganic & medicinal chemistry letters"],"pubmed_title":["Induction of apoptosis promoted by Bang52; a small molecule that downregulates Bcl-x(L)."],"pmcid":["PMC2808702"],"funding_grant_id":["P30 CA021765","CA6320","Z01 DK031123-04","CA21765","Z01 DK031123-03","ZIA DK031123-05"],"pubmed_authors":["Zambetti GP","Mazur S","Bang JK","Rossi M","Appella DH","Iera JA","Phillips DC"],"additional_accession":[]},"is_claimable":false,"name":"Induction of apoptosis promoted by Bang52; a small molecule that downregulates Bcl-x(L).","description":"Cancer cells evade death by over-producing specific proteins that inhibit apoptosis. One such group of proteins is the Bcl-2 family, of which Bcl-x(L) is an important member. This protein binds and inhibits BAK, another protein that promotes apoptosis. While the development of chemical inhibitors that block Bcl-x(L)-BAK association have been the focus of intense research efforts, we demonstrate in this manuscript an alternative strategy to downregulate Bcl-x(L). We have identified a small molecule (Bang52) that induces apoptosis in a lymphoblast-derived cell line by lowering levels of Bcl-x(L). Since Bang52 bears no resemblance to any chemical binder of Bcl-x(L) we believe that degradation of the protein is stimulated by a new type of pathway. These findings highlight a novel approach to the development of small molecules that promote apoptosis.","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 May","modification":"2020-10-31T09:41:35Z","creation":"2019-03-27T00:28:03Z"},"accession":"S-EPMC2808702","cross_references":{"pubmed":["19349174"],"doi":["10.1016/j.bmcl.2009.03.067"]}}