{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["84(3)"],"submitter":["Osterlund P"],"pubmed_abstract":["In less than 3 months after the first cases of swine origin 2009 influenza A (H1N1) virus infections were reported from Mexico, WHO declared a pandemic. The pandemic virus is antigenically distinct from seasonal influenza viruses, and the majority of human population lacks immunity against this virus. We have studied the activation of innate immune responses in pandemic virus-infected human monocyte-derived dendritic cells (DC) and macrophages. Pandemic A/Finland/553/2009 virus, representing a typical North American/European lineage virus, replicated very well in these cells. The pandemic virus, as well as the seasonal A/Brisbane/59/07 (H1N1) and A/New Caledonia/20/99 (H1N1) viruses, induced type I (alpha/beta interferon [IFN-alpha/beta]) and type III (IFN-lambda1 to -lambda3) IFN, CXCL10,"],"journal":["Journal of virology"],"pagination":["1414-22"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2812319"],"repository":["biostudies-literature"],"pubmed_title":["Pandemic H1N1 2009 influenza A virus induces weak cytokine responses in human macrophages and dendritic cells and is highly sensitive to the antiviral actions of interferons."],"pmcid":["PMC2812319"],"pubmed_authors":["Ikonen N","Osterlund P","Broman M","Hamming OJ","Hartmann R","Ziegler T","Strengell M","Julkunen I","Pirhonen J","Ronkko E","Makela SM"],"additional_accession":[]},"is_claimable":false,"name":"Pandemic H1N1 2009 influenza A virus induces weak cytokine responses in human macrophages and dendritic cells and is highly sensitive to the antiviral actions of interferons.","description":"In less than 3 months after the first cases of swine origin 2009 influenza A (H1N1) virus infections were reported from Mexico, WHO declared a pandemic. The pandemic virus is antigenically distinct from seasonal influenza viruses, and the majority of human population lacks immunity against this virus. We have studied the activation of innate immune responses in pandemic virus-infected human monocyte-derived dendritic cells (DC) and macrophages. Pandemic A/Finland/553/2009 virus, representing a typical North American/European lineage virus, replicated very well in these cells. The pandemic virus, as well as the seasonal A/Brisbane/59/07 (H1N1) and A/New Caledonia/20/99 (H1N1) viruses, induced type I (alpha/beta interferon [IFN-alpha/beta]) and type III (IFN-lambda1 to -lambda3) IFN, CXCL10,","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Feb","modification":"2025-04-04T10:32:30.934Z","creation":"2019-03-27T00:28:11Z"},"accession":"S-EPMC2812319","cross_references":{"pubmed":["19939920"],"doi":["10.1128/JVI.01619-09","10.1128/jvi.01619-09"]}}