{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sutton PL"],"funding":["NIAID NIH HHS"],"pagination":["3"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2818648"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["Background
Plasmodium falciparum re-emerged in Iquitos, Peru in 1994 and is now hypoendemic (< 0.5 infections/person/year). Purportedly non-immune individuals with discrete (non-overlapping) P. falciparum infections can be followed using this population dynamic. Previous work demonstrated a strong association between this population's antibody response to PfMSP1-19KD and protection against febrile illness and parasitaemia. Therefore, some selection for PfMSP1-19KD allelic diversity would be expected if the protection is to allele-specific sites of PfMSP1-19KD. Here, the potential for allele-specific polymorphisms in this population is investigated, and the allele-specificity of antibody responses to PfMSP1-19KD are determined.Methods
The 42KD region in PfMSP1 was genotyped "],"journal":["Malaria journal"],"pubmed_title":["The Plasmodium falciparum merozoite surface protein-1 19 KD antibody response in the Peruvian Amazon predominantly targets the non-allele specific, shared sites of this antigen."],"pmcid":["PMC2818648"],"funding_grant_id":["R01 AI064831"],"pubmed_authors":["Sutton PL","Branch OH","Clark EH","Silva C"],"additional_accession":[]},"is_claimable":false,"name":"The Plasmodium falciparum merozoite surface protein-1 19 KD antibody response in the Peruvian Amazon predominantly targets the non-allele specific, shared sites of this antigen.","description":"Background
Plasmodium falciparum re-emerged in Iquitos, Peru in 1994 and is now hypoendemic (< 0.5 infections/person/year). Purportedly non-immune individuals with discrete (non-overlapping) P. falciparum infections can be followed using this population dynamic. Previous work demonstrated a strong association between this population's antibody response to PfMSP1-19KD and protection against febrile illness and parasitaemia. Therefore, some selection for PfMSP1-19KD allelic diversity would be expected if the protection is to allele-specific sites of PfMSP1-19KD. Here, the potential for allele-specific polymorphisms in this population is investigated, and the allele-specificity of antibody responses to PfMSP1-19KD are determined.Methods
The 42KD region in PfMSP1 was genotyped ","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Jan","modification":"2026-04-07T15:40:39.329Z","creation":"2019-03-27T00:28:26Z"},"accession":"S-EPMC2818648","cross_references":{"pubmed":["20047674"],"doi":["10.1186/1475-2875-9-3"]}}