{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["30(5)"],"submitter":["Lecomte V"],"pubmed_abstract":["The role of the transcription factors sterol regulatory element binding protein 1a (SREBP-1a) and SREBP-1c in the regulation of cholesterol and fatty acid metabolism has been well studied; however, little is known about their specific function in muscle. In the present study, analysis of recent microarray data from muscle cells overexpressing SREBP1 suggested that they may play a role in the regulation of myogenesis. We then demonstrated that SREBP-1a and -1c inhibit myoblast-to-myotube differentiation and also induce in vivo and in vitro muscle atrophy. Furthermore, we have identified the transcriptional repressors BHLHB2 and BHLHB3 as mediators of these effects of SREBP-1a and -1c in muscle. Both repressors are SREBP-1 target genes, and they affect the expression of numerous genes involv"],"journal":["Molecular and cellular biology"],"pagination":["1182-98"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2820883"],"repository":["biostudies-literature"],"pubmed_title":["A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation."],"pmcid":["PMC2820883"],"pubmed_authors":["Durand C","Euthine V","Rome S","Lefai E","Vidal H","Meugnier E","Freyssenet D","Nemoz G","Lecomte V"],"additional_accession":[]},"is_claimable":false,"name":"A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation.","description":"The role of the transcription factors sterol regulatory element binding protein 1a (SREBP-1a) and SREBP-1c in the regulation of cholesterol and fatty acid metabolism has been well studied; however, little is known about their specific function in muscle. In the present study, analysis of recent microarray data from muscle cells overexpressing SREBP1 suggested that they may play a role in the regulation of myogenesis. We then demonstrated that SREBP-1a and -1c inhibit myoblast-to-myotube differentiation and also induce in vivo and in vitro muscle atrophy. Furthermore, we have identified the transcriptional repressors BHLHB2 and BHLHB3 as mediators of these effects of SREBP-1a and -1c in muscle. Both repressors are SREBP-1 target genes, and they affect the expression of numerous genes involv","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Mar","modification":"2025-06-01T02:29:39.341Z","creation":"2019-06-06T21:53:16Z"},"accession":"S-EPMC2820883","cross_references":{"pubmed":["20028734"],"doi":["10.1128/MCB.00690-09","10.1128/mcb.00690-09"]}}