biostudies-literatureGopal SMNIGMS NIH HHS1266-81https://www.ebi.ac.uk/biostudies/studies/S-EPMC2822037biostudies-literatureUnknown78(5)The new coarse graining model PRIMO/PRIMONA for proteins and nucleic acids is proposed. This model combines one to several heavy atoms into coarse-grained sites that are chosen to allow an analytical, high-resolution reconstruction of all-atom models based on molecular bonding geometry constraints. The accuracy of proposed reconstruction method in terms of structure and energetics is tested and compared with other popular reconstruction methods for a variety of protein and nucleic acid test sets.ProteinsPRIMO/PRIMONA: a coarse-grained model for proteins and nucleic acids that preserves near-atomistic accuracy.PMC2822037R01 GM084953R01 GM092949GM 084953R01 GM084953-02Cheng YMGopal SMMukherjee SFeig MfalsePRIMO/PRIMONA: a coarse-grained model for proteins and nucleic acids that preserves near-atomistic accuracy.The new coarse graining model PRIMO/PRIMONA for proteins and nucleic acids is proposed. This model combines one to several heavy atoms into coarse-grained sites that are chosen to allow an analytical, high-resolution reconstruction of all-atom models based on molecular bonding geometry constraints. The accuracy of proposed reconstruction method in terms of structure and energetics is tested and compared with other popular reconstruction methods for a variety of protein and nucleic acid test sets.2010-01-01T00:00:00Z2010 Apr2020-11-19T15:59:01Z2019-03-27T00:14:06ZS-EPMC28220371996778710.1002/prot.22645