biostudies-literatureUnknown54(3)Holzel CSCoresistance to human reserve antibiotics can be selected by antibiotics used in veterinary medicine. A Clostridium perfringens strain isolated from pig manure was resistant to the reserve drug linezolid and, simultaneously, resistant against florfenicol and erythromycin. We detected a new mutation in a highly conserved region of rplD, encoding protein L4 of the 50S ribosomal subunit. This is the first genetic substantiation of linezolid resistance in the genus Clostridium.Antimicrobial agents and chemotherapy1351-3https://www.ebi.ac.uk/biostudies/studies/S-EPMC2825973biostudies-literatureResistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4.PMC2825973Schwaiger KHolzel CSHarms KSBauer JfalseResistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4.Coresistance to human reserve antibiotics can be selected by antibiotics used in veterinary medicine. A Clostridium perfringens strain isolated from pig manure was resistant to the reserve drug linezolid and, simultaneously, resistant against florfenicol and erythromycin. We detected a new mutation in a highly conserved region of rplD, encoding protein L4 of the 50S ribosomal subunit. This is the first genetic substantiation of linezolid resistance in the genus Clostridium.2010-01-01T00:00:00Z2010 Mar2024-11-10T02:48:08.541Z2019-03-27T00:28:48ZS-EPMC28259732006506010.1128/aac.01208-0910.1128/AAC.01208-09