{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":42,"searchCount":0},"additional":{"submitter":["Ball ND"],"funding":["NIGMS NIH HHS"],"pagination":["2878-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2832076"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["132(9)"],"pubmed_abstract":["This communication describes oxidatively induced Ar-CF(3) bond-forming reductive elimination from new Pd(II) complexes of general structure (L approximately L)Pd(II)(Ar)(CF(3)). The electrophilic fluorinating reagent N-fluoro-2,4,6-trimethylpyridinium triflate promotes these reactions in good to excellent yields. The palladium(IV) intermediate ((t)Bu-bpy)Pd(IV)(CF(3))(F)(OTf)(C(6)H(4)F) has been isolated, characterized, and demonstrated to undergo high yielding Ar-CF(3) coupling upon thermolysis. This work provides an attractive conceptual framework for the development of Pd(II/IV)-catalyzed arene trifluoromethylation reactions."],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Aryl-CF(3) bond-forming reductive elimination from palladium(IV)."],"pmcid":["PMC2832076"],"funding_grant_id":["F31 GM089141","R01 GM073836-05","F31GM089141","F31 GM089141-01","R01 GM073836","GM073836"],"pubmed_authors":["Ball ND","Sanford MS","Kampf JW"],"view_count":["42"],"additional_accession":[]},"is_claimable":false,"name":"Aryl-CF(3) bond-forming reductive elimination from palladium(IV).","description":"This communication describes oxidatively induced Ar-CF(3) bond-forming reductive elimination from new Pd(II) complexes of general structure (L approximately L)Pd(II)(Ar)(CF(3)). The electrophilic fluorinating reagent N-fluoro-2,4,6-trimethylpyridinium triflate promotes these reactions in good to excellent yields. The palladium(IV) intermediate ((t)Bu-bpy)Pd(IV)(CF(3))(F)(OTf)(C(6)H(4)F) has been isolated, characterized, and demonstrated to undergo high yielding Ar-CF(3) coupling upon thermolysis. This work provides an attractive conceptual framework for the development of Pd(II/IV)-catalyzed arene trifluoromethylation reactions.","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Mar","modification":"2020-10-29T14:27:24Z","creation":"2019-03-26T23:28:35Z"},"accession":"S-EPMC2832076","cross_references":{"pubmed":["20155920"],"doi":["10.1021/ja100955x"]}}