{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Turk EM"],"funding":["NICHD NIH HHS","NIGMS NIH HHS"],"pagination":["8585-94"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2838280"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["285(12)"],"pubmed_abstract":["Yeast Suv3p is a member of the DEXH/D box family of RNA helicases and is a critical component of the mitochondrial degradosome, which also includes a 3' --> 5' exonuclease, Dss1p. Defects in the degradosome result in accumulation of aberrant transcripts, unprocessed transcripts, and excised group I introns. In addition, defects in SUV3 result in decreased splicing of the aI5beta and bI3 group I introns. Whereas a role for Suv3p in RNA degradation is well established, the function of Suv3p in splicing of group I introns has remained elusive. It has been particularly challenging to determine if Suv3p effects group I intron splicing through RNA degradation as part of the degradosome, or has a direct role in splicing as a chaperone, because nearly all perturbations of SUV3 or DSS1 result in lo"],"journal":["The Journal of biological chemistry"],"pubmed_title":["Splicing of yeast aI5beta group I intron requires SUV3 to recycle MRS1 via mitochondrial degradosome-promoted decay of excised intron ribonucleoprotein (RNP)."],"pmcid":["PMC2838280"],"funding_grant_id":["T32HD007104","F32GM078969","T32 HD007104","F32 GM078969","R01 GM062853","GM-62853"],"pubmed_authors":["Caprara MG","Turk EM"],"additional_accession":[]},"is_claimable":false,"name":"Splicing of yeast aI5beta group I intron requires SUV3 to recycle MRS1 via mitochondrial degradosome-promoted decay of excised intron ribonucleoprotein (RNP).","description":"Yeast Suv3p is a member of the DEXH/D box family of RNA helicases and is a critical component of the mitochondrial degradosome, which also includes a 3' --> 5' exonuclease, Dss1p. Defects in the degradosome result in accumulation of aberrant transcripts, unprocessed transcripts, and excised group I introns. In addition, defects in SUV3 result in decreased splicing of the aI5beta and bI3 group I introns. Whereas a role for Suv3p in RNA degradation is well established, the function of Suv3p in splicing of group I introns has remained elusive. It has been particularly challenging to determine if Suv3p effects group I intron splicing through RNA degradation as part of the degradosome, or has a direct role in splicing as a chaperone, because nearly all perturbations of SUV3 or DSS1 result in lo","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Mar","modification":"2026-04-14T23:11:41.628Z","creation":"2019-03-27T00:29:21Z"},"accession":"S-EPMC2838280","cross_references":{"pubmed":["20064926"],"doi":["10.1074/jbc.M109.090761","10.1074/jbc.m109.090761"]}}