{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ingason A"],"funding":["Medical Research Council","NIMH NIH HHS","Wellcome Trust"],"pagination":["1379-86"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2838541"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(7)"],"pubmed_abstract":["The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18,920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 x 10(-5)-1.7 x 10(-"],"journal":["Human molecular genetics"],"pubmed_title":["A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia."],"pmcid":["PMC2838541"],"funding_grant_id":["G0801418B","G0800509","G9817803B","076113","R01 MH078075"],"pubmed_authors":["Kahn RS","Murray R","Suvisaari J","Di Forti M","Cichon S","Hartmann AM","Rietschel M","Nothen MM","de Haan L","Jurgens G","Vasilescu C","Andreassen OA","Tosato S","Linszen D","Bruggeman R","Lerer B","Pietilainen OP","Ophoff RA","Melle I","Muglia P","Krabbendam L","van Os J","Owen MJ","Moller HJ","Tuulio-Henriksson A","Cantor RM","Ingason A","Rasmussen HB","O'Donovan MC","Walshe M","Bonetto C","Vassos E","Djurovic S","Werge T","Muhleisen TW","Nielsen J","Francks C","Collier DA","Cahn W","Strengman E","St Clair D","Giegling I","Rujescu D","Wiersma D","Hansen T","Craddock N","GROUP Investigators","Lonnqvist J","Peltonen L","Myin-Germeys I"],"additional_accession":[]},"is_claimable":false,"name":"A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia.","description":"The Abelson helper integration site 1 (AHI1) gene locus on chromosome 6q23 is among a group of candidate loci for schizophrenia susceptibility that were initially identified by linkage followed by linkage disequilibrium mapping, and subsequent replication of the association in an independent sample. Here, we present results of a replication study of AHI1 locus markers, previously implicated in schizophrenia, in a large European sample (in total 3907 affected and 7429 controls). Furthermore, we perform a meta-analysis of the implicated markers in 4496 affected and 18,920 controls. Both the replication study of new samples and the meta-analysis show evidence for significant overrepresentation of all tested alleles in patients compared with controls (meta-analysis; P = 8.2 x 10(-5)-1.7 x 10(-","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Apr","modification":"2026-04-14T23:15:56.759Z","creation":"2026-04-07T13:49:52.103Z"},"accession":"S-EPMC2838541","cross_references":{"pubmed":["20071346"],"doi":["10.1093/hmg/ddq009"]}}