{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(3)"],"submitter":["Romanowska M"],"funding":["Cancer Research UK"],"pubmed_abstract":["<h4>Background</h4>Psoriasis is one of the most frequent skin diseases world-wide. The disease impacts enormously on affected patients and poses a huge financial burden on health care providers. Several lines of evidence suggest that the nuclear hormone receptor peroxisome proliferator activator (PPAR) beta/delta, known to regulate epithelial differentiation and wound healing, contributes to psoriasis pathogenesis. It is unclear, however, whether activation of PPARbeta/delta is sufficient to trigger psoriasis-like changes in vivo.<h4>Methodology/principal findings</h4>Using immunohistochemistry, we define the distribution of PPARbeta/delta in the skin lesions of psoriasis. By expression profiling, we confirm that PPARbeta/delta is overexpressed in the vast majority of psoriasis patients. W"],"journal":["PloS one"],"pagination":["e9701"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2838790"],"repository":["biostudies-literature"],"pubmed_title":["Activation of PPARbeta/delta causes a psoriasis-like skin disease in vivo."],"pmcid":["PMC2838790"],"pubmed_authors":["Romanowska M","Foerster J","Palmer CN","Reilly L","Gustafsson MC"],"additional_accession":[]},"is_claimable":false,"name":"Activation of PPARbeta/delta causes a psoriasis-like skin disease in vivo.","description":"<h4>Background</h4>Psoriasis is one of the most frequent skin diseases world-wide. The disease impacts enormously on affected patients and poses a huge financial burden on health care providers. Several lines of evidence suggest that the nuclear hormone receptor peroxisome proliferator activator (PPAR) beta/delta, known to regulate epithelial differentiation and wound healing, contributes to psoriasis pathogenesis. It is unclear, however, whether activation of PPARbeta/delta is sufficient to trigger psoriasis-like changes in vivo.<h4>Methodology/principal findings</h4>Using immunohistochemistry, we define the distribution of PPARbeta/delta in the skin lesions of psoriasis. By expression profiling, we confirm that PPARbeta/delta is overexpressed in the vast majority of psoriasis patients. W","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Mar","modification":"2026-04-14T23:16:43.368Z","creation":"2019-03-26T23:07:27Z"},"accession":"S-EPMC2838790","cross_references":{"pubmed":["20300524"],"doi":["10.1371/journal.pone.0009701"]}}