biostudies-literatureUnknown5(3)Romanowska MCancer Research UK<h4>Background</h4>Psoriasis is one of the most frequent skin diseases world-wide. The disease impacts enormously on affected patients and poses a huge financial burden on health care providers. Several lines of evidence suggest that the nuclear hormone receptor peroxisome proliferator activator (PPAR) beta/delta, known to regulate epithelial differentiation and wound healing, contributes to psoriasis pathogenesis. It is unclear, however, whether activation of PPARbeta/delta is sufficient to trigger psoriasis-like changes in vivo.<h4>Methodology/principal findings</h4>Using immunohistochemistry, we define the distribution of PPARbeta/delta in the skin lesions of psoriasis. By expression profiling, we confirm that PPARbeta/delta is overexpressed in the vast majority of psoriasis patients. WPloS onee9701https://www.ebi.ac.uk/biostudies/studies/S-EPMC2838790biostudies-literatureActivation of PPARbeta/delta causes a psoriasis-like skin disease in vivo.PMC2838790Romanowska MFoerster JPalmer CNReilly LGustafsson MCfalseActivation of PPARbeta/delta causes a psoriasis-like skin disease in vivo.<h4>Background</h4>Psoriasis is one of the most frequent skin diseases world-wide. The disease impacts enormously on affected patients and poses a huge financial burden on health care providers. Several lines of evidence suggest that the nuclear hormone receptor peroxisome proliferator activator (PPAR) beta/delta, known to regulate epithelial differentiation and wound healing, contributes to psoriasis pathogenesis. It is unclear, however, whether activation of PPARbeta/delta is sufficient to trigger psoriasis-like changes in vivo.<h4>Methodology/principal findings</h4>Using immunohistochemistry, we define the distribution of PPARbeta/delta in the skin lesions of psoriasis. By expression profiling, we confirm that PPARbeta/delta is overexpressed in the vast majority of psoriasis patients. W2010-01-01T00:00:00Z2010 Mar2026-04-14T23:16:43.368Z2019-03-26T23:07:27ZS-EPMC28387902030052410.1371/journal.pone.0009701