biostudies-literatureKoutros SIntramural NIH HHSNCI NIH HHS2389-96https://www.ebi.ac.uk/biostudies/studies/S-EPMC2840184biostudies-literatureUnknown70(6)The phosphatidylinositol 3-kinase (PI3K) pathway regulates various cellular processes, including cellular proliferation and intracellular trafficking, and may affect prostate carcinogenesis. Thus, we explored the association between single-nucleotide polymorphisms (SNP) in PI3K genes and prostate cancer. Pooled data from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium were examined for associations between 89 SNPs in PI3K genes (PIK3C2B, PIK3AP1, PIK3C2A, PIK3CD, and PIK3R3) and prostate cancer risk in 8,309 cases and 9,286 controls. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using logistic regression. SNP rs7556371 in PIK3C2B was significantly associated with prostate cancer risk [OR(per allele), 1.08 (95% CI, 1.03-1.14); P(trend) = 0.Cancer researchPooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer.PMC2840184U01 CA098758UO1CA98758UO1 CA98710UO1 CA98216U01 CA098216Z01 CP010152U01 CA098233UO1CA98233Z99 CA999999U01 CA098710Diver WRHuang WYFeigelson HSKaaks RSchumacher FRThomas GBerndt SIKolonel LNHunter DJLe Marchand LKoutros SGiovanucci EYeager MThun MJHaiman CARiboli EChanock SJStampfer MJStram DOHayes RBAlbanes DHenderson BESiddiq AMa JKraft PTravis RCCrawford EDCanzian FfalsePooled analysis of phosphatidylinositol 3-kinase pathway variants and risk of prostate cancer.The phosphatidylinositol 3-kinase (PI3K) pathway regulates various cellular processes, including cellular proliferation and intracellular trafficking, and may affect prostate carcinogenesis. Thus, we explored the association between single-nucleotide polymorphisms (SNP) in PI3K genes and prostate cancer. Pooled data from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium were examined for associations between 89 SNPs in PI3K genes (PIK3C2B, PIK3AP1, PIK3C2A, PIK3CD, and PIK3R3) and prostate cancer risk in 8,309 cases and 9,286 controls. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using logistic regression. SNP rs7556371 in PIK3C2B was significantly associated with prostate cancer risk [OR(per allele), 1.08 (95% CI, 1.03-1.14); P(trend) = 0.2010-01-01T00:00:00Z2010 Mar2026-05-05T00:33:52.863Z2026-04-07T21:09:00.752ZS-EPMC28401842019746010.1158/0008-5472.CAN-09-357510.1158/0008-5472.can-09-3575