{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["102(6)"],"submitter":["Berthier A"],"pubmed_abstract":["<h4>Background</h4>This study evaluates the relation of the early oestrogen-regulated gene gabarapl1 to cellular growth and its prognostic significance in breast adenocarcinoma.<h4>Methods</h4>First, the relation between GABARAPL1 expression and MCF-7 growth rate was analysed. Thereafter, by performing macroarray and reverse transcriptase quantitative-polymerase chain reaction (RT-qPCR) experiments, gabarapl1 expression was quantified in several histological breast tumour types and in a retrospective cohort of 265 breast cancers.<h4>Results</h4>GABARAPL1 overexpression inhibited MCF-7 growth rate and gabarapl1 expression was downregulated in breast tumours. Gabarapl1 mRNA levels were found to be significantly lower in tumours presenting a high histological grade, with a lymph node-positive"],"journal":["British journal of cancer"],"pagination":["1024-31"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2844027"],"repository":["biostudies-literature"],"pubmed_title":["High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer."],"pmcid":["PMC2844027"],"pubmed_authors":["Boyer-Guittaut M","Berthier A","Bobin JY","Seguin S","Descotes F","Fraichard A","Tolle F","Jouvenot M","Datchary J","Sasco AJ","De Laroche G","Rodriguez-Lafrasse C","Saez S","Delage-Mourroux R"],"additional_accession":[]},"is_claimable":false,"name":"High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer.","description":"<h4>Background</h4>This study evaluates the relation of the early oestrogen-regulated gene gabarapl1 to cellular growth and its prognostic significance in breast adenocarcinoma.<h4>Methods</h4>First, the relation between GABARAPL1 expression and MCF-7 growth rate was analysed. Thereafter, by performing macroarray and reverse transcriptase quantitative-polymerase chain reaction (RT-qPCR) experiments, gabarapl1 expression was quantified in several histological breast tumour types and in a retrospective cohort of 265 breast cancers.<h4>Results</h4>GABARAPL1 overexpression inhibited MCF-7 growth rate and gabarapl1 expression was downregulated in breast tumours. Gabarapl1 mRNA levels were found to be significantly lower in tumours presenting a high histological grade, with a lymph node-positive","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Mar","modification":"2025-04-26T17:34:09.281Z","creation":"2019-06-06T21:57:29Z"},"accession":"S-EPMC2844027","cross_references":{"pubmed":["20197771"],"doi":["10.1038/sj.bjc.6605568"]}}