biostudies-literatureUnknown102(6)Berthier A<h4>Background</h4>This study evaluates the relation of the early oestrogen-regulated gene gabarapl1 to cellular growth and its prognostic significance in breast adenocarcinoma.<h4>Methods</h4>First, the relation between GABARAPL1 expression and MCF-7 growth rate was analysed. Thereafter, by performing macroarray and reverse transcriptase quantitative-polymerase chain reaction (RT-qPCR) experiments, gabarapl1 expression was quantified in several histological breast tumour types and in a retrospective cohort of 265 breast cancers.<h4>Results</h4>GABARAPL1 overexpression inhibited MCF-7 growth rate and gabarapl1 expression was downregulated in breast tumours. Gabarapl1 mRNA levels were found to be significantly lower in tumours presenting a high histological grade, with a lymph node-positiveBritish journal of cancer1024-31https://www.ebi.ac.uk/biostudies/studies/S-EPMC2844027biostudies-literatureHigh expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer.PMC2844027Boyer-Guittaut MBerthier ABobin JYSeguin SDescotes FFraichard ATolle FJouvenot MDatchary JSasco AJDe Laroche GRodriguez-Lafrasse CSaez SDelage-Mourroux RfalseHigh expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer.<h4>Background</h4>This study evaluates the relation of the early oestrogen-regulated gene gabarapl1 to cellular growth and its prognostic significance in breast adenocarcinoma.<h4>Methods</h4>First, the relation between GABARAPL1 expression and MCF-7 growth rate was analysed. Thereafter, by performing macroarray and reverse transcriptase quantitative-polymerase chain reaction (RT-qPCR) experiments, gabarapl1 expression was quantified in several histological breast tumour types and in a retrospective cohort of 265 breast cancers.<h4>Results</h4>GABARAPL1 overexpression inhibited MCF-7 growth rate and gabarapl1 expression was downregulated in breast tumours. Gabarapl1 mRNA levels were found to be significantly lower in tumours presenting a high histological grade, with a lymph node-positive2010-01-01T00:00:00Z2010 Mar2025-04-26T17:34:09.281Z2019-06-06T21:57:29ZS-EPMC28440272019777110.1038/sj.bjc.6605568