{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yamada Y"],"funding":["Medical Research Council","Wellcome Trust Program","Wellcome Trust"],"pagination":["390-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2845816"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["339(2)"],"pubmed_abstract":["The mature fruiting body of Dictyostelium consists of stalk and spore cells but its construction, and the migration of the preceding slug stage, requires a number of specialized sub-types of prestalk cell whose nature and function are not well understood. The prototypic prestalk-specific gene, ecmA, is inducible by the polyketide DIF-1 in a monolayer assay and requires the DimB and MybE transcription factors for full inducibility. We perform genome-wide microarray analyses, on parental, mybE- and dimB- cells, and identify many additional genes that depend on MybE and DimB for their DIF-1 inducibility. Surprisingly, an even larger number of genes are only DIF inducible in mybE- cells, some genes are only inducible in DimB- cells and some are inducible when either transcription factor is abs"],"journal":["Developmental biology"],"pubmed_title":["A new Dictyostelium prestalk cell sub-type."],"pmcid":["PMC2845816"],"funding_grant_id":["053640/Z","MC_U105115237","053640"],"pubmed_authors":["Williams JG","Kay RR","Bloomfield G","Yamada Y","Ivens A","Ross S"],"additional_accession":[]},"is_claimable":false,"name":"A new Dictyostelium prestalk cell sub-type.","description":"The mature fruiting body of Dictyostelium consists of stalk and spore cells but its construction, and the migration of the preceding slug stage, requires a number of specialized sub-types of prestalk cell whose nature and function are not well understood. The prototypic prestalk-specific gene, ecmA, is inducible by the polyketide DIF-1 in a monolayer assay and requires the DimB and MybE transcription factors for full inducibility. We perform genome-wide microarray analyses, on parental, mybE- and dimB- cells, and identify many additional genes that depend on MybE and DimB for their DIF-1 inducibility. Surprisingly, an even larger number of genes are only DIF inducible in mybE- cells, some genes are only inducible in DimB- cells and some are inducible when either transcription factor is abs","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Mar","modification":"2026-04-18T11:11:19.735Z","creation":"2026-04-07T14:35:33.368Z"},"accession":"S-EPMC2845816","cross_references":{"pubmed":["20080085"],"doi":["10.1016/j.ydbio.2009.12.045"]}}