{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yu GJ"],"funding":["NIGMS NIH HHS"],"pagination":["7422-6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2847632"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["57(16)"],"pubmed_abstract":["A collection of 91 3-(arylthiomethyl)isoxazole-4,5-dicarboxamides was prepared starting from dimethyl 3-(chloromethyl)isoxazole-4,5-dicarboxylate. The thioether moieties in these compounds were subsequently oxidized to give the corresponding 3-(arylsulfonylmethyl)isoxazole-4,5-dicarboxamides. By carefully controlling stoichiometry and reaction conditions, the C4 and C5 carbomethoxy groups could be differentially derivatized to carboxamides. A total of 182 trisubstituted isoxazoles are reported and deposited in the National Institutes of Health Molecular Repository; an 80 compound subset was evaluated for insecticidal activity."],"journal":["Journal of agricultural and food chemistry"],"pubmed_title":["3-(Arylthiomethyl)isoxazole-4,5-dicarboxamides: chemoselective nucleophilic chemistry and insecticidal activity."],"pmcid":["PMC2847632"],"funding_grant_id":["P41 GM076151","P41 GM089153","GM076151","P41 GM076151-03"],"pubmed_authors":["Robins LI","Sparks TC","Yu GJ","Iwamoto S","Kurth MJ","Lorsbach BA","Fettinger JC"],"additional_accession":[]},"is_claimable":false,"name":"3-(Arylthiomethyl)isoxazole-4,5-dicarboxamides: chemoselective nucleophilic chemistry and insecticidal activity.","description":"A collection of 91 3-(arylthiomethyl)isoxazole-4,5-dicarboxamides was prepared starting from dimethyl 3-(chloromethyl)isoxazole-4,5-dicarboxylate. The thioether moieties in these compounds were subsequently oxidized to give the corresponding 3-(arylsulfonylmethyl)isoxazole-4,5-dicarboxamides. By carefully controlling stoichiometry and reaction conditions, the C4 and C5 carbomethoxy groups could be differentially derivatized to carboxamides. A total of 182 trisubstituted isoxazoles are reported and deposited in the National Institutes of Health Molecular Repository; an 80 compound subset was evaluated for insecticidal activity.","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Aug","modification":"2025-04-04T19:58:21.165Z","creation":"2019-03-27T00:29:47Z"},"accession":"S-EPMC2847632","cross_references":{"pubmed":["19624156"],"doi":["10.1021/jf901512t"]}}