biostudies-literatureFeng FNIDCR NIH HHS20-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC2848819biostudies-literatureUnknown16(1)<h4>Objective</h4>Periodontal disease is an inflammatory disorder with widespread morbidities involving both oral and systemic health. The primary goal of periodontal treatment is the regeneration of the lost or diseased periodontium. In this study, we retrospectively examined feasibility and safety of reconstructing the periodontal intrabony defects with autologous periodontal ligament progenitor (PDLP) implantation in three patients.<h4>Materials and methods</h4>In this retrospective pilot study, we treated 16 teeth with at least one deep intrabony defect of probing depth (PD) > OR = 6 mm with PDLP transplantation and evaluated clinical outcome measures in terms of probing depth, gingival recession and attachment gain for a duration of 32-72 months. Furthermore, we compare PDLPs with staOral diseasesUtility of PDL progenitors for in vivo tissue regeneration: a report of 3 cases.PMC2848819R01 DE019156R01 DE019156-05R21 DE017632R21 DE017632-02Liu YHuang GTYamaza TShi SAkiyama KWang SWang TMFeng FChen JHWang BBfalseUtility of PDL progenitors for in vivo tissue regeneration: a report of 3 cases.<h4>Objective</h4>Periodontal disease is an inflammatory disorder with widespread morbidities involving both oral and systemic health. The primary goal of periodontal treatment is the regeneration of the lost or diseased periodontium. In this study, we retrospectively examined feasibility and safety of reconstructing the periodontal intrabony defects with autologous periodontal ligament progenitor (PDLP) implantation in three patients.<h4>Materials and methods</h4>In this retrospective pilot study, we treated 16 teeth with at least one deep intrabony defect of probing depth (PD) > OR = 6 mm with PDLP transplantation and evaluated clinical outcome measures in terms of probing depth, gingival recession and attachment gain for a duration of 32-72 months. Furthermore, we compare PDLPs with sta2010-01-01T00:00:00Z2010 Jan2025-04-05T15:34:22.846Z2019-03-27T00:29:50ZS-EPMC28488192035527810.1111/j.1601-0825.2009.01593.x