{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kang M"],"funding":["NIDDK NIH HHS"],"pagination":["1226-35"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2848927"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["159(6)"],"pubmed_abstract":["<h4>Background and purpose</h4>Excitation-transcriptional coupling involves communication between plasma membrane ion channels and gene expression in the nucleus. Calcium influx through L-type Ca(2+) channels induces phosphorylation of the transcription factor, cyclic-AMP response element binding protein (CREB) and downstream activation of the cyclic-AMP response element (CRE) promoter regions. Tyrosine nitration of Ca(2+) channels attenuates interactions with c-Src kinase, decreasing Ca(2+) channel currents and smooth muscle contraction during colonic inflammation. In this study we examined the effect of tyrosine nitration and colonic inflammation on Ca(2+) channel mediated phosphorylation of CREB and CRE activation.<h4>Experimental approach</h4>CREB and phospho-CREB were detected by West"],"journal":["British journal of pharmacology"],"pubmed_title":["The effect of tyrosine nitration of L-type Ca2+ channels on excitation-transcription coupling in colonic inflammation."],"pmcid":["PMC2848927"],"funding_grant_id":["R01 DK046367","DK046367"],"pubmed_authors":["Kang M","Akbarali HI","Ross GR"],"additional_accession":[]},"is_claimable":false,"name":"The effect of tyrosine nitration of L-type Ca2+ channels on excitation-transcription coupling in colonic inflammation.","description":"<h4>Background and purpose</h4>Excitation-transcriptional coupling involves communication between plasma membrane ion channels and gene expression in the nucleus. Calcium influx through L-type Ca(2+) channels induces phosphorylation of the transcription factor, cyclic-AMP response element binding protein (CREB) and downstream activation of the cyclic-AMP response element (CRE) promoter regions. Tyrosine nitration of Ca(2+) channels attenuates interactions with c-Src kinase, decreasing Ca(2+) channel currents and smooth muscle contraction during colonic inflammation. In this study we examined the effect of tyrosine nitration and colonic inflammation on Ca(2+) channel mediated phosphorylation of CREB and CRE activation.<h4>Experimental approach</h4>CREB and phospho-CREB were detected by West","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Mar","modification":"2025-06-01T00:53:52.622Z","creation":"2019-06-06T21:58:35Z"},"accession":"S-EPMC2848927","cross_references":{"pubmed":["20128810"],"doi":["10.1111/j.1476-5381.2009.00599.x"]}}