{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(4)"],"submitter":["Aron L"],"pubmed_abstract":["The mechanisms underlying the selective death of substantia nigra (SN) neurons in Parkinson disease (PD) remain elusive. While inactivation of DJ-1, an oxidative stress suppressor, causes PD, animal models lacking DJ-1 show no overt dopaminergic (DA) neuron degeneration in the SN. Here, we show that aging mice lacking DJ-1 and the GDNF-receptor Ret in the DA system display an accelerated loss of SN cell bodies, but not axons, compared to mice that only lack Ret signaling. The survival requirement for DJ-1 is specific for the GIRK2-positive subpopulation in the SN which projects exclusively to the striatum and is more vulnerable in PD. Using Drosophila genetics, we show that constitutively active Ret and associated Ras/ERK, but not PI3K/Akt, signaling components interact genetically with DJ"],"journal":["PLoS biology"],"pagination":["e1000349"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2850379"],"repository":["biostudies-literature"],"pubmed_title":["Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons."],"pmcid":["PMC2850379"],"pubmed_authors":["Klein R","Klein P","Aron L","Wurst W","Pham TT","Kramer ER"],"additional_accession":[]},"is_claimable":false,"name":"Pro-survival role for Parkinson's associated gene DJ-1 revealed in trophically impaired dopaminergic neurons.","description":"The mechanisms underlying the selective death of substantia nigra (SN) neurons in Parkinson disease (PD) remain elusive. While inactivation of DJ-1, an oxidative stress suppressor, causes PD, animal models lacking DJ-1 show no overt dopaminergic (DA) neuron degeneration in the SN. Here, we show that aging mice lacking DJ-1 and the GDNF-receptor Ret in the DA system display an accelerated loss of SN cell bodies, but not axons, compared to mice that only lack Ret signaling. The survival requirement for DJ-1 is specific for the GIRK2-positive subpopulation in the SN which projects exclusively to the striatum and is more vulnerable in PD. Using Drosophila genetics, we show that constitutively active Ret and associated Ras/ERK, but not PI3K/Akt, signaling components interact genetically with DJ","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Apr","modification":"2025-04-22T01:04:52.077Z","creation":"2019-03-27T00:29:58Z"},"accession":"S-EPMC2850379","cross_references":{"pubmed":["20386724"],"doi":["10.1371/journal.pbio.1000349"]}}