biostudies-literatureFaghihi MANINDS NIH HHS637-43https://www.ebi.ac.uk/biostudies/studies/S-EPMC2850559biostudies-literatureUnknown10(9)Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform group of regulatory RNAs but instead belong to multiple categories with some common features. Recent evidence indicates that antisense transcripts are frequently functional and use diverse transcriptional and post-transcriptional gene regulatory mechanisms to carry out a wide variety of biological roles.Nature reviews. Molecular cell biologyRegulatory roles of natural antisense transcripts.PMC2850559R01 NS063974-01A1R01 NS063974Faghihi MAWahlestedt CfalseRegulatory roles of natural antisense transcripts.Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform group of regulatory RNAs but instead belong to multiple categories with some common features. Recent evidence indicates that antisense transcripts are frequently functional and use diverse transcriptional and post-transcriptional gene regulatory mechanisms to carry out a wide variety of biological roles.2009-01-01T00:00:00Z2009 Sep2020-11-01T08:16:44Z2019-03-27T00:29:55ZS-EPMC28505591963899910.1038/nrm2738