{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(5)"],"submitter":["Jaubert-Possamai S"],"pubmed_abstract":["The pathways that allow short noncoding RNAs such as the microRNAs (miRNAs) to mediate gene regulation and control critical cellular and developmental processes involve a limited number of key protein components. These proteins are the Dicer-like RNases, double-stranded RNA (dsRNA)-binding proteins, and the Argonaute (AGO) proteins that process stem-loop hairpin transcripts of endogenous genes to generate miRNAs or long dsRNA precursors (either exogenous or endogenous). Comparative genomics studies of metazoans have shown the pathways to be highly conserved overall; the major difference observed is that the vertebrate pathways overlap in sharing a single Dicer (DCR) and AGO proteins, whereas those of insects appear to be parallel, with distinct Dicers and AGOs required for each pathway. Th"],"journal":["Molecular biology and evolution"],"pagination":["979-87"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2857804"],"repository":["biostudies-literature"],"pubmed_title":["Expansion of the miRNA pathway in the hemipteran insect Acyrthosiphon pisum."],"pmcid":["PMC2857804"],"pubmed_authors":["Rispe C","Gordon K","Walsh T","Tagu D","Jaubert-Possamai S","Tanguy S","Edwards O"],"additional_accession":[]},"is_claimable":false,"name":"Expansion of the miRNA pathway in the hemipteran insect Acyrthosiphon pisum.","description":"The pathways that allow short noncoding RNAs such as the microRNAs (miRNAs) to mediate gene regulation and control critical cellular and developmental processes involve a limited number of key protein components. These proteins are the Dicer-like RNases, double-stranded RNA (dsRNA)-binding proteins, and the Argonaute (AGO) proteins that process stem-loop hairpin transcripts of endogenous genes to generate miRNAs or long dsRNA precursors (either exogenous or endogenous). Comparative genomics studies of metazoans have shown the pathways to be highly conserved overall; the major difference observed is that the vertebrate pathways overlap in sharing a single Dicer (DCR) and AGO proteins, whereas those of insects appear to be parallel, with distinct Dicers and AGOs required for each pathway. Th","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 May","modification":"2025-04-04T13:38:36.914Z","creation":"2019-03-27T00:30:16Z"},"accession":"S-EPMC2857804","cross_references":{"pubmed":["20179251"],"doi":["10.1093/molbev/msp256"]}}