biostudies-literatureKollar VHungarian Science Foundation838530https://www.ebi.ac.uk/biostudies/studies/S-EPMC2857871biostudies-literatureUnknown2010Titin is a giant filamentous protein traversing the half sarcomere of striated muscle with putative functions as diverse as providing structural template, generating elastic response, and sensing and relaying mechanical information. The Z-disk region of titin, which corresponds to the N-terminal end of the molecule, has been thought to be a hot spot for mechanosensing while also serving as anchorage for its sarcomeric attachment. Understanding the mechanics of titin's Z-disk region, particularly under the effect of binding proteins, is of great interest. Here we briefly review recent findings on the structure, molecular associations, and mechanics of titin's Z-disk region. In addition, we report experimental results on the dynamic strength of titin's Z1Z2 domains measured by nanomechanicalJournal of biomedicine & biotechnologyDynamic strength of titin's Z-disk end.PMC2857871K73256KFKT-1-2006-0021F49514OMFB-380/2006Szatmari DGrama LKollar VKellermayer MSfalseDynamic strength of titin's Z-disk end.Titin is a giant filamentous protein traversing the half sarcomere of striated muscle with putative functions as diverse as providing structural template, generating elastic response, and sensing and relaying mechanical information. The Z-disk region of titin, which corresponds to the N-terminal end of the molecule, has been thought to be a hot spot for mechanosensing while also serving as anchorage for its sarcomeric attachment. Understanding the mechanics of titin's Z-disk region, particularly under the effect of binding proteins, is of great interest. Here we briefly review recent findings on the structure, molecular associations, and mechanics of titin's Z-disk region. In addition, we report experimental results on the dynamic strength of titin's Z1Z2 domains measured by nanomechanical2010-01-01T00:00:00Z20102025-06-01T11:59:38.5Z2019-03-27T00:30:16ZS-EPMC28578712041436410.1155/2010/838530