biostudies-literatureUnknown10Askie LM<h4>Background</h4>Preterm infants requiring assisted ventilation are at significant risk of both pulmonary and cerebral injury. Inhaled Nitric Oxide, an effective therapy for pulmonary hypertension and hypoxic respiratory failure in the full term infant, has also been studied in preterm infants. The most recent Cochrane review of preterm infants includes 11 studies and 3,370 participants. The results show a statistically significant reduction in the combined outcome of death or chronic lung disease (CLD) in two studies with routine use of iNO in intubated preterm infants. However, uncertainty remains as a larger study (Kinsella 2006) showed no significant benefit for iNO for this combined outcome. Also, trials that included very ill infants do not demonstrate significant benefit. One triaBMC pediatrics15https://www.ebi.ac.uk/biostudies/studies/S-EPMC2860486biostudies-literatureInhaled nitric oxide in preterm infants: a systematic review and individual patient data meta-analysis.PMC2860486Hardy PEhrenkranz RACutter GKinsella JPBallard RAHibbs AMRosskamp RRich WWilliamson ECecchi AHuo DZCarberry AEFiner NPerritt KHascoet JMField DElbourne DTruog WVoysey MRaquel GBVan Meurs KPAskie LMMeta-Analysis of Preterm Patients on inhaled Nitric Oxide (MAPPiNO) CollaborationDani CBlack DBrajkovic IBaldassarre JSSubhedar NVLei WMercier JCSchreiber MDYoung JDas ACzepla OSrisuparp PBarrington KfalseInhaled nitric oxide in preterm infants: a systematic review and individual patient data meta-analysis.<h4>Background</h4>Preterm infants requiring assisted ventilation are at significant risk of both pulmonary and cerebral injury. Inhaled Nitric Oxide, an effective therapy for pulmonary hypertension and hypoxic respiratory failure in the full term infant, has also been studied in preterm infants. The most recent Cochrane review of preterm infants includes 11 studies and 3,370 participants. The results show a statistically significant reduction in the combined outcome of death or chronic lung disease (CLD) in two studies with routine use of iNO in intubated preterm infants. However, uncertainty remains as a larger study (Kinsella 2006) showed no significant benefit for iNO for this combined outcome. Also, trials that included very ill infants do not demonstrate significant benefit. One tria2010-01-01T00:00:00Z2010 Mar2025-04-22T05:06:39.28Z2019-03-27T00:30:22ZS-EPMC28604862033189910.1186/1471-2431-10-15