{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ju J"],"funding":["NIEHS NIH HHS","NCI NIH HHS"],"pagination":["533-42"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2860705"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(4)"],"pubmed_abstract":["The cancer-preventive activity of vitamin E has been studied. Whereas some epidemiological studies have suggested a protective effect of vitamin E against cancer formation, many large-scale intervention studies with alpha-tocopherol (usually large doses) have not demonstrated a cancer-preventive effect. Studies on alpha-tocopherol in animal models also have not demonstrated robust cancer prevention effects. One possible explanation for the lack of demonstrable cancer-preventive effects is that high doses of alpha-tocopherol decrease the blood and tissue levels of delta-tocopherols. It has been suggested that gamma-tocopherol, due to its strong anti-inflammatory and other activities, may be the more effective form of vitamin E in cancer prevention. Our recent results have demonstrated that a gamma-tocopherol-rich mixture of tocopherols inhibits colon, prostate, mammary and lung tumorigenesis in animal models, suggesting that this mixture may have a high potential for applications in the prevention of human cancer. In this review, we discuss biochemical properties of tocopherols, results of possible cancer-preventive effects in humans and animal models and possible mechanisms involved in the inhibition of carcinogenesis. Based on this information, we propose that a gamma-tocopherol-rich mixture of tocopherols is a very promising cancer-preventive agent and warrants extensive future research."],"journal":["Carcinogenesis"],"pubmed_title":["Cancer-preventive activities of tocopherols and tocotrienols."],"pmcid":["PMC2860705"],"funding_grant_id":["CA120915","R01 CA122474","CA122474","CA108455-05","R01 CA122474-04","CA133021","P30 ES005022"],"pubmed_authors":["Yang CS","Yang Z","Ju J","Picinich SC","Kong AN","Suh N","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"Cancer-preventive activities of tocopherols and tocotrienols.","description":"The cancer-preventive activity of vitamin E has been studied. Whereas some epidemiological studies have suggested a protective effect of vitamin E against cancer formation, many large-scale intervention studies with alpha-tocopherol (usually large doses) have not demonstrated a cancer-preventive effect. Studies on alpha-tocopherol in animal models also have not demonstrated robust cancer prevention effects. One possible explanation for the lack of demonstrable cancer-preventive effects is that high doses of alpha-tocopherol decrease the blood and tissue levels of delta-tocopherols. It has been suggested that gamma-tocopherol, due to its strong anti-inflammatory and other activities, may be the more effective form of vitamin E in cancer prevention. Our recent results have demonstrated that a gamma-tocopherol-rich mixture of tocopherols inhibits colon, prostate, mammary and lung tumorigenesis in animal models, suggesting that this mixture may have a high potential for applications in the prevention of human cancer. In this review, we discuss biochemical properties of tocopherols, results of possible cancer-preventive effects in humans and animal models and possible mechanisms involved in the inhibition of carcinogenesis. Based on this information, we propose that a gamma-tocopherol-rich mixture of tocopherols is a very promising cancer-preventive agent and warrants extensive future research.","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Apr","modification":"2021-03-07T08:54:29Z","creation":"2019-03-27T00:30:23Z"},"accession":"S-EPMC2860705","cross_references":{"pubmed":["19748925"],"doi":["10.1093/carcin/bgp205"]}}