{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jin B"],"funding":["NCI NIH HHS"],"pagination":["14356-65"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2863211"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["285(19)"],"pubmed_abstract":["Nuclear factor-kappaB (NF-kappaB)-based signaling regulates diverse biological processes, and its deregulation is associated with various disorders including autoimmune diseases and cancer. Identification of novel factors that modulate NF-kappaB function is therefore of significant importance. The Mastermind-like 1 (MAML1) transcriptional co-activator regulates transcriptional activity in the Notch pathway and is emerging as a co-activator of other pathways. In this study, we found that MAML1 regulates NF-kappaB signaling via two mechanisms. First, MAML1 co-activates the NF-kappaB subunit RelA (p65) in NF-kappaB-dependent transcription. Second, MAML1 causes degradation of the inhibitor of NF-kappaB (IkappaBalpha). Maml1-deficient mouse embryonic fibroblasts showed impaired tumor necrosis f"],"journal":["The Journal of biological chemistry"],"pubmed_title":["The mastermind-like 1 (MAML1) co-activator regulates constitutive NF-kappaB signaling and cell survival."],"pmcid":["PMC2863211"],"funding_grant_id":["R01 CA036167","R01 CA097148"],"pubmed_authors":["Griffin JD","Wu L","Lin S","Jin B","Chen Z","Li JL","Shen H"],"additional_accession":[]},"is_claimable":false,"name":"The mastermind-like 1 (MAML1) co-activator regulates constitutive NF-kappaB signaling and cell survival.","description":"Nuclear factor-kappaB (NF-kappaB)-based signaling regulates diverse biological processes, and its deregulation is associated with various disorders including autoimmune diseases and cancer. Identification of novel factors that modulate NF-kappaB function is therefore of significant importance. The Mastermind-like 1 (MAML1) transcriptional co-activator regulates transcriptional activity in the Notch pathway and is emerging as a co-activator of other pathways. In this study, we found that MAML1 regulates NF-kappaB signaling via two mechanisms. First, MAML1 co-activates the NF-kappaB subunit RelA (p65) in NF-kappaB-dependent transcription. Second, MAML1 causes degradation of the inhibitor of NF-kappaB (IkappaBalpha). Maml1-deficient mouse embryonic fibroblasts showed impaired tumor necrosis f","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 May","modification":"2025-04-04T11:56:11.543Z","creation":"2019-03-27T00:30:30Z"},"accession":"S-EPMC2863211","cross_references":{"pubmed":["20231278"],"doi":["10.1074/jbc.m109.078865","10.1074/jbc.M109.078865"]}}