{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mathiason CK"],"funding":["NIAID NIH HHS"],"pagination":["5097-107"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2863796"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["84(10)"],"pubmed_abstract":["Substantial evidence for prion transmission via blood transfusion exists for many transmissible spongiform encephalopathy (TSE) diseases. Determining which cell phenotype(s) is responsible for trafficking infectivity has important implications for our understanding of the dissemination of prions, as well as their detection and elimination from blood products. We used bioassay studies of native white-tailed deer and transgenic cervidized mice to determine (i) if chronic wasting disease (CWD) blood infectivity is associated with the cellular versus the cell-free/plasma fraction of blood and (ii) in particular if B-cell (MAb 2-104(+)), platelet (CD41/61(+)), or CD14(+) monocyte blood cell phenotypes harbor infectious prions. All four deer transfused with the blood mononuclear cell fraction fr"],"journal":["Journal of virology"],"pubmed_title":["B cells and platelets harbor prion infectivity in the blood of deer infected with chronic wasting disease."],"pmcid":["PMC2863796"],"funding_grant_id":["N01AI25491"],"pubmed_authors":["Warren RJ","Young AJ","Miller KV","Hayes-Klug J","Mason GL","Hoover EA","Mathiason CK","Telling GC","Osborn DA","Dahmes SJ","Hays SA","Powers J"],"additional_accession":[]},"is_claimable":false,"name":"B cells and platelets harbor prion infectivity in the blood of deer infected with chronic wasting disease.","description":"Substantial evidence for prion transmission via blood transfusion exists for many transmissible spongiform encephalopathy (TSE) diseases. Determining which cell phenotype(s) is responsible for trafficking infectivity has important implications for our understanding of the dissemination of prions, as well as their detection and elimination from blood products. We used bioassay studies of native white-tailed deer and transgenic cervidized mice to determine (i) if chronic wasting disease (CWD) blood infectivity is associated with the cellular versus the cell-free/plasma fraction of blood and (ii) in particular if B-cell (MAb 2-104(+)), platelet (CD41/61(+)), or CD14(+) monocyte blood cell phenotypes harbor infectious prions. All four deer transfused with the blood mononuclear cell fraction fr","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 May","modification":"2025-04-04T11:55:59.919Z","creation":"2019-03-27T00:30:33Z"},"accession":"S-EPMC2863796","cross_references":{"pubmed":["20219916"],"doi":["10.1128/JVI.02169-09","10.1128/jvi.02169-09"]}}