{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wuthrich C"],"funding":["NINDS NIH HHS"],"pagination":["742-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2865689"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["65(6)"],"pubmed_abstract":["The polyomavirus JC (JCV) is the causative agent of progressive multifocal leukoencephalopathy and of JCV granule cell neuronopathy. We present a human immunodeficiency virus-negative patient who experienced development of multiple cortical lesions, aphasia, and progressive cognitive decline after chemotherapy for non-small-cell lung cancer. Brain biopsy and cerebrospinal fluid polymerase chain reaction demonstrated JCV, and she had a rapidly fatal outcome. Postmortem analysis showed diffuse cortical lesions and areas of necrosis at the gray-white junction. Immunostaining showed a productive JCV infection of cortical pyramidal neurons, confirmed by electron microscopy, with limited demyelination. This novel gray matter syndrome expands the scope of JCV clinical presentation and pathogenesis."],"journal":["Annals of neurology"],"pubmed_title":["Fulminant JC virus encephalopathy with productive infection of cortical pyramidal neurons."],"pmcid":["PMC2865689"],"funding_grant_id":["K24 NS060950-03","K24 NS 060950","R01 NS041198-09","R01 NS047029","1K02NS054674","R01 NS041198","R01 NS057444","K24 NS060950","R01 NS 041198","R01 NS 057444","R01 NS047029-06","R01 NS 047029"],"pubmed_authors":["Maheshwari A","Anderson MP","Westmoreland S","Ropper AH","Viscidi RP","Koralnik IJ","McKay J","Wuthrich C","Dang X"],"additional_accession":[]},"is_claimable":false,"name":"Fulminant JC virus encephalopathy with productive infection of cortical pyramidal neurons.","description":"The polyomavirus JC (JCV) is the causative agent of progressive multifocal leukoencephalopathy and of JCV granule cell neuronopathy. We present a human immunodeficiency virus-negative patient who experienced development of multiple cortical lesions, aphasia, and progressive cognitive decline after chemotherapy for non-small-cell lung cancer. Brain biopsy and cerebrospinal fluid polymerase chain reaction demonstrated JCV, and she had a rapidly fatal outcome. Postmortem analysis showed diffuse cortical lesions and areas of necrosis at the gray-white junction. Immunostaining showed a productive JCV infection of cortical pyramidal neurons, confirmed by electron microscopy, with limited demyelination. This novel gray matter syndrome expands the scope of JCV clinical presentation and pathogenesis.","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Jun","modification":"2024-11-06T00:43:53.315Z","creation":"2019-03-27T00:30:37Z"},"accession":"S-EPMC2865689","cross_references":{"pubmed":["19557867"],"doi":["10.1002/ana.21619"]}}