{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rosenthal J"],"funding":["NIGMS NIH HHS"],"pagination":["5536-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2866442"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["132(16)"],"pubmed_abstract":["The synthesis, photophysical properties, and a biological application of BODIPY-triazole 1 (BOT1) are described. BOT1 juxtaposes a BODIPY fluorophore with a tripodal ligand platform via a triazole bridge. The triazole linker is afforded by azide-alkyne \"click\" chemistry and comprises the third arm of the tripodal architecture. BOT1 binds Cu(2+) in aqueous solution to form a Cu(II)[BOT1] complex in which emission from the BODIPY moiety is efficiently quenched. This complex exhibits a prompt turn-on response when exposed to nitroxyl, and this emission response is specific to HNO over other reactive nitrogen and oxygen species. Notably, Cu(II)[BOT1] does not fluoresce in the presence of nitric oxide, making this system the first discrete molecular probe capable of detecting HNO over NO under "],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Direct detection of nitroxyl in aqueous solution using a tripodal copper(II) BODIPY complex."],"pmcid":["PMC2866442"],"funding_grant_id":["F32 GM080060","F32 GM080060-02","F32 GM080060-03"],"pubmed_authors":["Lippard SJ","Rosenthal J"],"additional_accession":[]},"is_claimable":false,"name":"Direct detection of nitroxyl in aqueous solution using a tripodal copper(II) BODIPY complex.","description":"The synthesis, photophysical properties, and a biological application of BODIPY-triazole 1 (BOT1) are described. BOT1 juxtaposes a BODIPY fluorophore with a tripodal ligand platform via a triazole bridge. The triazole linker is afforded by azide-alkyne \"click\" chemistry and comprises the third arm of the tripodal architecture. BOT1 binds Cu(2+) in aqueous solution to form a Cu(II)[BOT1] complex in which emission from the BODIPY moiety is efficiently quenched. This complex exhibits a prompt turn-on response when exposed to nitroxyl, and this emission response is specific to HNO over other reactive nitrogen and oxygen species. Notably, Cu(II)[BOT1] does not fluoresce in the presence of nitric oxide, making this system the first discrete molecular probe capable of detecting HNO over NO under ","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Apr","modification":"2025-04-21T16:08:03.875Z","creation":"2019-03-26T23:28:37Z"},"accession":"S-EPMC2866442","cross_references":{"pubmed":["20355724"],"doi":["10.1021/ja909148v"]}}