{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zheng Y"],"funding":["NIDDK NIH HHS","NIGMS NIH HHS"],"pagination":["407-15"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2867294"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["189(3)"],"pubmed_abstract":["Histone H1 phosphorylation affects chromatin condensation and function, but little is known about how specific phosphorylations impact the function of H1 variants in higher eukaryotes. In this study, we show that specific sites in H1.2 and H1.4 of human cells are phosphorylated only during mitosis or during both mitosis and interphase. Antisera generated to individual H1.2/H1.4 interphase phosphorylations reveal that they are distributed throughout nuclei and enriched in nucleoli. Moreover, interphase phosphorylated H1.4 is enriched at active 45S preribosomal RNA gene promoters and is rapidly induced at steroid hormone response elements by hormone treatment. Our results imply that site-specific interphase H1 phosphorylation facilitates transcription by RNA polymerases I and II and has an u"],"journal":["The Journal of cell biology"],"pubmed_title":["Histone H1 phosphorylation is associated with transcription by RNA polymerases I and II."],"pmcid":["PMC2867294"],"funding_grant_id":["T32 GM008276","R01 DK053884","R01 DK53884","GM 067193","5T32 GM 08276","R01 GM067193"],"pubmed_authors":["Zheng Y","Mizzen CA","Nardulli AM","Schultz-Norton JR","Schiltz RL","Kelleher NL","John S","Pesavento JJ","Hager GL","Baek S"],"additional_accession":[]},"is_claimable":false,"name":"Histone H1 phosphorylation is associated with transcription by RNA polymerases I and II.","description":"Histone H1 phosphorylation affects chromatin condensation and function, but little is known about how specific phosphorylations impact the function of H1 variants in higher eukaryotes. In this study, we show that specific sites in H1.2 and H1.4 of human cells are phosphorylated only during mitosis or during both mitosis and interphase. Antisera generated to individual H1.2/H1.4 interphase phosphorylations reveal that they are distributed throughout nuclei and enriched in nucleoli. Moreover, interphase phosphorylated H1.4 is enriched at active 45S preribosomal RNA gene promoters and is rapidly induced at steroid hormone response elements by hormone treatment. Our results imply that site-specific interphase H1 phosphorylation facilitates transcription by RNA polymerases I and II and has an u","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 May","modification":"2026-05-03T10:40:23.877Z","creation":"2025-04-04T07:45:32.741Z"},"accession":"S-EPMC2867294","cross_references":{"pubmed":["20439994"],"doi":["10.1083/jcb.201001148"]}}