{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8"],"submitter":["Bentz EK"],"pubmed_abstract":["<h4>Background</h4>The stem cell marker Octamer-4 (OCT-4) is expressed in human endometrium. Menstrual cycle-dependency of OCT-4 expression has not been investigated to date.<h4>Methods</h4>In a prospective, single center cohort study of 98 women undergoing hysteroscopy during the follicular (n = 49) and the luteal (n = 40) phases of the menstrual cycle, we obtained endometrial samples. Specimens were investigated for OCT-4 expression on the mRNA and protein levels using reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry. Expression of OCT-4 was correlated to menstrual cycle phase.<h4>Results</h4>Of 89 women sampled, 49 were in the follicular phase and 40 were in the luteal phase. OCT-4 mRNA was detected in all samples. Increased OCT-4 mRNA levels in the foll"],"journal":["Reproductive biology and endocrinology : RB&E"],"pagination":["38"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2867815"],"repository":["biostudies-literature"],"pubmed_title":["OCT-4 expression in follicular and luteal phase endometrium: a pilot study."],"pmcid":["PMC2867815"],"pubmed_authors":["Tempfer CB","Kenning M","Hefler LA","Bentz EK","Schneeberger C","Kolbus A","Huber JC"],"additional_accession":[]},"is_claimable":false,"name":"OCT-4 expression in follicular and luteal phase endometrium: a pilot study.","description":"<h4>Background</h4>The stem cell marker Octamer-4 (OCT-4) is expressed in human endometrium. Menstrual cycle-dependency of OCT-4 expression has not been investigated to date.<h4>Methods</h4>In a prospective, single center cohort study of 98 women undergoing hysteroscopy during the follicular (n = 49) and the luteal (n = 40) phases of the menstrual cycle, we obtained endometrial samples. Specimens were investigated for OCT-4 expression on the mRNA and protein levels using reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry. Expression of OCT-4 was correlated to menstrual cycle phase.<h4>Results</h4>Of 89 women sampled, 49 were in the follicular phase and 40 were in the luteal phase. OCT-4 mRNA was detected in all samples. Increased OCT-4 mRNA levels in the foll","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Apr","modification":"2025-04-21T16:09:50.513Z","creation":"2019-03-27T00:30:43Z"},"accession":"S-EPMC2867815","cross_references":{"pubmed":["20412569"],"doi":["10.1186/1477-7827-8-38"]}}