biostudies-literatureUnknown8Bentz EK<h4>Background</h4>The stem cell marker Octamer-4 (OCT-4) is expressed in human endometrium. Menstrual cycle-dependency of OCT-4 expression has not been investigated to date.<h4>Methods</h4>In a prospective, single center cohort study of 98 women undergoing hysteroscopy during the follicular (n = 49) and the luteal (n = 40) phases of the menstrual cycle, we obtained endometrial samples. Specimens were investigated for OCT-4 expression on the mRNA and protein levels using reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry. Expression of OCT-4 was correlated to menstrual cycle phase.<h4>Results</h4>Of 89 women sampled, 49 were in the follicular phase and 40 were in the luteal phase. OCT-4 mRNA was detected in all samples. Increased OCT-4 mRNA levels in the follReproductive biology and endocrinology : RB&E38https://www.ebi.ac.uk/biostudies/studies/S-EPMC2867815biostudies-literatureOCT-4 expression in follicular and luteal phase endometrium: a pilot study.PMC2867815Tempfer CBKenning MHefler LABentz EKSchneeberger CKolbus AHuber JCfalseOCT-4 expression in follicular and luteal phase endometrium: a pilot study.<h4>Background</h4>The stem cell marker Octamer-4 (OCT-4) is expressed in human endometrium. Menstrual cycle-dependency of OCT-4 expression has not been investigated to date.<h4>Methods</h4>In a prospective, single center cohort study of 98 women undergoing hysteroscopy during the follicular (n = 49) and the luteal (n = 40) phases of the menstrual cycle, we obtained endometrial samples. Specimens were investigated for OCT-4 expression on the mRNA and protein levels using reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry. Expression of OCT-4 was correlated to menstrual cycle phase.<h4>Results</h4>Of 89 women sampled, 49 were in the follicular phase and 40 were in the luteal phase. OCT-4 mRNA was detected in all samples. Increased OCT-4 mRNA levels in the foll2010-01-01T00:00:00Z2010 Apr2025-04-21T16:09:50.513Z2019-03-27T00:30:43ZS-EPMC28678152041256910.1186/1477-7827-8-38