{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou Y"],"funding":["NCI NIH HHS"],"pagination":["7904-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2867889"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["107(17)"],"pubmed_abstract":["MicroRNAs (miRNAs) are noncoding RNAs that regulate global gene expression. miRNAs often act synergistically to repress target genes, and their dysregulation can contribute to the initiation and progression of a variety of cancers. The clinical relationship between global expression of miRNA and mRNA in cancer has not been studied in detail. We used whole-genome microarray analyses of CD138-enriched plasma cells from 52 newly diagnosed cases of multiple myeloma to correlate miRNA expression profiles with a validated mRNA-based risk stratification score, proliferation index, and predefined gene sets. In stark contrast to mRNAs, we discovered that all tested miRNAs were significantly up-regulated in high-risk disease as defined by a validated 70-gene risk score (P < 0.01) and proliferation i"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["High-risk myeloma is associated with global elevation of miRNAs and overexpression of EIF2C2/AGO2."],"pmcid":["PMC2867889"],"funding_grant_id":["CA55819","P01 CA055819"],"pubmed_authors":["Stephens O","Waheed S","Williams DR","Barlogie B","Anaissie E","Chen L","Zhou Y","Pineda-Roman M","Shaughnessy JD","Alsayed Y","Cartron MA","Nair B","van Rhee F","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"High-risk myeloma is associated with global elevation of miRNAs and overexpression of EIF2C2/AGO2.","description":"MicroRNAs (miRNAs) are noncoding RNAs that regulate global gene expression. miRNAs often act synergistically to repress target genes, and their dysregulation can contribute to the initiation and progression of a variety of cancers. The clinical relationship between global expression of miRNA and mRNA in cancer has not been studied in detail. We used whole-genome microarray analyses of CD138-enriched plasma cells from 52 newly diagnosed cases of multiple myeloma to correlate miRNA expression profiles with a validated mRNA-based risk stratification score, proliferation index, and predefined gene sets. In stark contrast to mRNAs, we discovered that all tested miRNAs were significantly up-regulated in high-risk disease as defined by a validated 70-gene risk score (P < 0.01) and proliferation i","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Apr","modification":"2026-05-05T06:16:56.432Z","creation":"2026-04-07T21:24:35.736Z"},"accession":"S-EPMC2867889","cross_references":{"pubmed":["20385818"],"doi":["10.1073/pnas.0908441107"]}}