{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["283(6)"],"submitter":["Mattiazzi M"],"pubmed_abstract":["Modulating composition and shape of biological membranes is an emerging mode of regulation of cellular processes. We investigated the global effects that such perturbations have on a model eukaryotic cell. Phospholipases A(2) (PLA(2)s), enzymes that cleave one fatty acid molecule from membrane phospholipids, exert their biological activities through affecting both membrane composition and shape. We have conducted a genome-wide analysis of cellular effects of a PLA(2) in the yeast Saccharomyces cerevisiae as a model system. We demonstrate functional genetic and biochemical interactions between PLA(2) activity and the Rim101 signaling pathway in S. cerevisiae. Our results suggest that the composition and/or the shape of the endosomal membrane affect the Rim101 pathway. We describe a genetica"],"journal":["Molecular genetics and genomics : MGG"],"pagination":["519-30"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2872012"],"repository":["biostudies-literature"],"pubmed_title":["Genetic interactions between a phospholipase A2 and the Rim101 pathway components in S. cerevisiae reveal a role for this pathway in response to changes in membrane composition and shape."],"pmcid":["PMC2872012"],"pubmed_authors":["Petrovic U","Mattiazzi M","Derisi JL","Kaferle P","Krizaj I","Jambhekar A"],"additional_accession":[]},"is_claimable":false,"name":"Genetic interactions between a phospholipase A2 and the Rim101 pathway components in S. cerevisiae reveal a role for this pathway in response to changes in membrane composition and shape.","description":"Modulating composition and shape of biological membranes is an emerging mode of regulation of cellular processes. We investigated the global effects that such perturbations have on a model eukaryotic cell. Phospholipases A(2) (PLA(2)s), enzymes that cleave one fatty acid molecule from membrane phospholipids, exert their biological activities through affecting both membrane composition and shape. We have conducted a genome-wide analysis of cellular effects of a PLA(2) in the yeast Saccharomyces cerevisiae as a model system. We demonstrate functional genetic and biochemical interactions between PLA(2) activity and the Rim101 signaling pathway in S. cerevisiae. Our results suggest that the composition and/or the shape of the endosomal membrane affect the Rim101 pathway. We describe a genetica","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Jun","modification":"2026-07-16T05:46:30.216Z","creation":"2025-05-29T22:06:56.819Z"},"accession":"S-EPMC2872012","cross_references":{"pubmed":["20379744"],"doi":["10.1007/s00438-010-0533-8"]}}