biostudies-literatureLencer RNCATS NIH HHSNCRR NIH HHSNIMH NIH HHSNational Institutes of HealthNIH/National Center for Research Resources (NCRR)/General Clinical Research Centers217-23https://www.ebi.ac.uk/biostudies/studies/S-EPMC2879155biostudies-literatureUnknown67(3)<h4>Background</h4>Smooth pursuit deficits are an intermediate phenotype for schizophrenia that may result from disturbances in visual motion perception, sensorimotor transformation, predictive mechanisms, or alterations in basic oculomotor control. Which of these components are the primary causes of smooth pursuit impairments and whether they are impaired similarly across psychotic disorders remain to be established.<h4>Methods</h4>First-episode psychotic patients with bipolar disorder (n = 34), unipolar depression (n = 24), or schizophrenia (n = 77) and matched healthy participants (n = 130) performed three smooth pursuit tasks designed to evaluate different components of pursuit tracking.<h4>Results</h4>On ramp tasks, maintenance pursuit velocity was reduced in all three patients groupsBiological psychiatrySensorimotor transformation deficits for smooth pursuit in first-episode affective psychoses and schizophrenia.PMC2879155M01 RR000056-44MH01433K02 MH001433-03MH45156MH62134R01 MH062134P50 MH045156M01 RR00056UL1 TR000005M01 RR000056P50 MH045156-090013R01 MH062134-06Keshavan MSReilly JLLencer RSprenger ASweeney JAHarris MSfalseSensorimotor transformation deficits for smooth pursuit in first-episode affective psychoses and schizophrenia.<h4>Background</h4>Smooth pursuit deficits are an intermediate phenotype for schizophrenia that may result from disturbances in visual motion perception, sensorimotor transformation, predictive mechanisms, or alterations in basic oculomotor control. Which of these components are the primary causes of smooth pursuit impairments and whether they are impaired similarly across psychotic disorders remain to be established.<h4>Methods</h4>First-episode psychotic patients with bipolar disorder (n = 34), unipolar depression (n = 24), or schizophrenia (n = 77) and matched healthy participants (n = 130) performed three smooth pursuit tasks designed to evaluate different components of pursuit tracking.<h4>Results</h4>On ramp tasks, maintenance pursuit velocity was reduced in all three patients groups2010-01-01T00:00:00Z2010 Feb2025-04-22T06:47:44.915Z2019-03-27T00:31:14ZS-EPMC28791551978296410.1016/j.biopsych.2009.08.005