{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hemingway H"],"funding":["British Heart Foundation","National Institute for Health Research (NIHR)"],"pagination":["e1000286"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2879408"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(6)"],"pubmed_abstract":["<h4>Background</h4>Systematic evaluations of the quality of research on a single prognostic biomarker are rare. We sought to evaluate the quality of prognostic research evidence for the association of C-reactive protein (CRP) with fatal and nonfatal events among patients with stable coronary disease.<h4>Methods and findings</h4>We searched MEDLINE (1966 to 2009) and EMBASE (1980 to 2009) and selected prospective studies of patients with stable coronary disease, reporting a relative risk for the association of CRP with death and nonfatal cardiovascular events. We included 83 studies, reporting 61,684 patients and 6,485 outcome events. No study reported a prespecified statistical analysis protocol; only two studies reported the time elapsed (in months or years) between initial presentation o"],"journal":["PLoS medicine"],"pubmed_title":["Evaluating the quality of research into a single prognostic biomarker: a systematic review and meta-analysis of 83 studies of C-reactive protein in stable coronary artery disease."],"pmcid":["PMC2879408"],"funding_grant_id":["RP-PG-0407-10314"],"pubmed_authors":["Abrams KR","Palmer S","Shipley M","Fitzpatrick NK","Hingorani AD","Hemingway H","Moreno S","Philipson P","Damant J","Timmis AD","McAllister KS","Kaski JC","Chen R"],"additional_accession":[]},"is_claimable":false,"name":"Evaluating the quality of research into a single prognostic biomarker: a systematic review and meta-analysis of 83 studies of C-reactive protein in stable coronary artery disease.","description":"<h4>Background</h4>Systematic evaluations of the quality of research on a single prognostic biomarker are rare. We sought to evaluate the quality of prognostic research evidence for the association of C-reactive protein (CRP) with fatal and nonfatal events among patients with stable coronary disease.<h4>Methods and findings</h4>We searched MEDLINE (1966 to 2009) and EMBASE (1980 to 2009) and selected prospective studies of patients with stable coronary disease, reporting a relative risk for the association of CRP with death and nonfatal cardiovascular events. We included 83 studies, reporting 61,684 patients and 6,485 outcome events. No study reported a prespecified statistical analysis protocol; only two studies reported the time elapsed (in months or years) between initial presentation o","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Jun","modification":"2025-04-22T06:41:22.551Z","creation":"2019-03-27T00:31:14Z"},"accession":"S-EPMC2879408","cross_references":{"pubmed":["20532236"],"doi":["10.1371/journal.pmed.1000286"]}}