biostudies-literatureXue BNLM NIH HHSNIGMS NIH HHSS1https://www.ebi.ac.uk/biostudies/studies/S-EPMC2880407biostudies-literatureUnknown4 Suppl 1<h4>Background</h4>Many proteins or their regions known as intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) lack unique 3D structure in their native states under physiological conditions yet fulfill key biological functions. Earlier bioinformatics studies showed that IDPs and IDRs are highly abundant in different proteomes and carry out mostly regulatory functions related to molecular recognition and signal transduction. Archaea belong to an intriguing domain of life whose members, being microbes, are characterized by a unique mosaic-like combination of bacterial and eukaryotic properties and include inhabitants of some of the most extreme environments on the planet. With the expansion of the archaea genome data (more than fifty archaea species from fiveBMC systems biologyArchaic chaos: intrinsically disordered proteins in Archaea.PMC2880407R01 LM007688-01A1GM071714-01A2Dunker AKXue BUversky VNWilliams RWOldfield CJfalseArchaic chaos: intrinsically disordered proteins in Archaea.<h4>Background</h4>Many proteins or their regions known as intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) lack unique 3D structure in their native states under physiological conditions yet fulfill key biological functions. Earlier bioinformatics studies showed that IDPs and IDRs are highly abundant in different proteomes and carry out mostly regulatory functions related to molecular recognition and signal transduction. Archaea belong to an intriguing domain of life whose members, being microbes, are characterized by a unique mosaic-like combination of bacterial and eukaryotic properties and include inhabitants of some of the most extreme environments on the planet. With the expansion of the archaea genome data (more than fifty archaea species from five2010-01-01T00:00:00Z2010 May2026-04-08T01:52:57.669Z2026-04-07T20:33:58.331ZS-EPMC28804072052225110.1186/1752-0509-4-S1-S1