{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Dobly A"],"pubmed_abstract":["<h4>Background</h4>The bovine spongiform encephalopathy (BSE) epidemic presented homogeneity of the phenotype. This classical BSE (called C-type) was probably due to the contamination of the food chain by a single prion strain. However, due to the active surveillance and better techniques, two rare variants of BSE have been recently reported in different continents without a clear correlation to the BSE epidemic. These emerging types behave as different strains of BSE and were named H-type and L-type according to the high and low molecular mass of the unglycosylated fragment of their proteinase K resistant prion protein (PrPres). In these types, the proportion of the un-, mono- and di-glycosylated fragments of PrP (glycoprofile) is also atypical and represents an effective diagnostic param"],"journal":["BMC veterinary research"],"pagination":["26"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2881063"],"repository":["biostudies-literature"],"pubmed_title":["No H- and L-type cases in Belgium in cattle diagnosed with bovine spongiform encephalopathy (1999-2008) aging seven years and older."],"pmcid":["PMC2881063"],"pubmed_authors":["Van Muylem P","Durand S","Geeroms R","Langeveld J","Vanopdenbosch E","Rodeghiero C","Roels S","De Sloovere J","Dobly A","van Keulen L"],"additional_accession":[]},"is_claimable":false,"name":"No H- and L-type cases in Belgium in cattle diagnosed with bovine spongiform encephalopathy (1999-2008) aging seven years and older.","description":"<h4>Background</h4>The bovine spongiform encephalopathy (BSE) epidemic presented homogeneity of the phenotype. This classical BSE (called C-type) was probably due to the contamination of the food chain by a single prion strain. However, due to the active surveillance and better techniques, two rare variants of BSE have been recently reported in different continents without a clear correlation to the BSE epidemic. These emerging types behave as different strains of BSE and were named H-type and L-type according to the high and low molecular mass of the unglycosylated fragment of their proteinase K resistant prion protein (PrPres). In these types, the proportion of the un-, mono- and di-glycosylated fragments of PrP (glycoprofile) is also atypical and represents an effective diagnostic param","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 May","modification":"2025-05-18T13:37:53.156Z","creation":"2025-05-18T13:37:53.156Z"},"accession":"S-EPMC2881063","cross_references":{"pubmed":["20492661"],"doi":["10.1186/1746-6148-6-26"]}}