biostudies-literatureXie XNIGMS NIH HHS3847-50https://www.ebi.ac.uk/biostudies/studies/S-EPMC2882174biostudies-literatureUnknown75(11)Alkylidenecyclopropanes can be synthesized from enantiomerically enriched cyclopropene derivatives with >99% stereotransfer and good to excellent yield. The protocol comprises the stereoselective reaction of Grignard reagents with 1-alkoxymethyl-3-hydroxymethylcyclopropenes and a stereospecific [1,3] carbon shift reaction.The Journal of organic chemistryStereospecific synthesis of alkylidenecyclopropanes via sequential cyclopropene carbomagnesation/1,3-carbon shift.PMC2882174R01 GM068640-07R01 GM068650R01 GM068640Yang ZFox JMXie XfalseStereospecific synthesis of alkylidenecyclopropanes via sequential cyclopropene carbomagnesation/1,3-carbon shift.Alkylidenecyclopropanes can be synthesized from enantiomerically enriched cyclopropene derivatives with >99% stereotransfer and good to excellent yield. The protocol comprises the stereoselective reaction of Grignard reagents with 1-alkoxymethyl-3-hydroxymethylcyclopropenes and a stereospecific [1,3] carbon shift reaction.2010-01-01T00:00:00Z2010 Jun2025-05-18T13:38:14.751Z2025-05-18T13:38:14.751ZS-EPMC28821742046220610.1021/jo1002938