{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hsu YH"],"funding":["NIA NIH HHS","NHLBI NIH HHS","Dutch Research Council (NWO)","European Commission FP7","NIAMS NIH HHS","Wellcome Trust","CIHR"],"pagination":["e1000977"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2883588"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(6)"],"pubmed_abstract":["Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons. Genome-wide association studies (GWAS) have become an unbiased approach to identify variations in the genome that potentially affect health. However, the genetic variants identified so far only explain a small proportion of the heritability for complex traits. Due to the modest genetic effect size and inadequate power, true association signals may not be revealed based on a stringent genome-wide significance threshold. Here, we take advantage of SNP and transcript arrays and integrate GWAS and expression signature profiling relevant to the skeletal system in cellular and animal models to prioritize the discovery of novel candidate genes for osteoporosis-related traits, including bone mineral density (BMD"],"journal":["PLoS genetics"],"pubmed_title":["An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits."],"pmcid":["PMC2883588"],"funding_grant_id":["FP7_201865","N01 HC025195","175.010.200","N02-HL-6-4278","N01-HC-25195","R01 AR/AG 41398","R01 AR 057118","R01 AR050066","R01 AR057118","R01 AR 050066","911-03-012","R01 AR041398"],"pubmed_authors":["Cupples LA","Nilsson O","Karasik D","Grundberg E","Uitterlinden AG","Kiel DP","Estrada K","Richards JB","Wilson SG","Spector TD","Hofman A","Liang L","Farber CR","Soranzo N","Bianchi EN","Hsu YH","Ferrari S","Zhai G","Zhou Y","Rivadeneira F","Moffatt MF","van Meurs JB","Schadt EE","Pols HA","Pastinen T","Zillikens MC","Lusis AJ","van Nas A","Price RI","Demissie S"],"additional_accession":[]},"is_claimable":false,"name":"An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.","description":"Osteoporosis is a complex disorder and commonly leads to fractures in elderly persons. Genome-wide association studies (GWAS) have become an unbiased approach to identify variations in the genome that potentially affect health. However, the genetic variants identified so far only explain a small proportion of the heritability for complex traits. Due to the modest genetic effect size and inadequate power, true association signals may not be revealed based on a stringent genome-wide significance threshold. Here, we take advantage of SNP and transcript arrays and integrate GWAS and expression signature profiling relevant to the skeletal system in cellular and animal models to prioritize the discovery of novel candidate genes for osteoporosis-related traits, including bone mineral density (BMD","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Jun","modification":"2026-04-07T20:19:53.422Z","creation":"2026-04-07T17:36:19.437Z"},"accession":"S-EPMC2883588","cross_references":{"pubmed":["20548944"],"doi":["10.1371/journal.pgen.1000977"]}}