{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lur G"],"funding":["Medical Research Council","Wellcome Trust"],"pagination":["1648-53"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC2887489"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(19)"],"pubmed_abstract":["Store-operated Ca(2+) entry is a ubiquitous mechanism that prevents the depletion of endoplasmic reticulum (ER) calcium. A reduction of ER calcium triggers translocation of STIM proteins, which serve as calcium sensors in the ER, to subplasmalemmal puncta where they interact with and activate Orai channels. In pancreatic acinar cells, inositol 1,4,5-trisphosphate (IP(3)) receptors populate the apical part of the ER. Here, however, we observe that STIM1 translocates exclusively to the lateral and basal regions following ER Ca(2+) loss. This finding is paradoxical because the basal and lateral regions of the acinar cells contain rough ER (RER); the size of the ribosomes that decorate RER is larger than the distance that can be spanned by a STIM-Orai complex, and STIM1 function should therefo"],"journal":["Current biology : CB"],"pubmed_title":["Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP(3) receptors."],"pmcid":["PMC2887489"],"funding_grant_id":["G0700167","074766","082151","G9900432","080906/Z/06/Z"],"pubmed_authors":["Haynes LP","Tepikin AV","Lur G","Feske S","Petersen OH","Gerasimenko OV","Burgoyne RD","Prior IA"],"additional_accession":[]},"is_claimable":false,"name":"Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP(3) receptors.","description":"Store-operated Ca(2+) entry is a ubiquitous mechanism that prevents the depletion of endoplasmic reticulum (ER) calcium. A reduction of ER calcium triggers translocation of STIM proteins, which serve as calcium sensors in the ER, to subplasmalemmal puncta where they interact with and activate Orai channels. In pancreatic acinar cells, inositol 1,4,5-trisphosphate (IP(3)) receptors populate the apical part of the ER. Here, however, we observe that STIM1 translocates exclusively to the lateral and basal regions following ER Ca(2+) loss. This finding is paradoxical because the basal and lateral regions of the acinar cells contain rough ER (RER); the size of the ribosomes that decorate RER is larger than the distance that can be spanned by a STIM-Orai complex, and STIM1 function should therefo","dates":{"release":"2009-01-01T00:00:00Z","publication":"2009 Oct","modification":"2025-04-26T18:58:11.155Z","creation":"2019-03-27T00:31:35Z"},"accession":"S-EPMC2887489","cross_references":{"pubmed":["19765991"],"doi":["10.1016/j.cub.2009.07.072"]}}